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  • SEEKING HEALTH Active Folate 60 pastylek
  • SEEKING HEALTH Active Folate 60 lozenges
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Active Folate Active Folate

Seeking Health Active Folate is a dietary supplement with two active forms of folates characterised by direct bioavailability – Quatrefolic® L-5-methyltetrahydrofolate   and calcium folinate in the dose of 800 mcg per capsule.

Folates are a natural form of vitamin B9. They are found mainly in greens, broccoli, asparagus, avocado and whole grains. Adequate folate levels in the body prevent the incidence of hyperhomocysteinaemia, impaired synthesis of purines and pyrimidine as well as abnormal DNA methylation.

Normal metabolism of folates reduces the incidence of cardiovascular and neurological disorders. In the case of pregnant women, it decreases also the risk of such complications as miscarriage, macrosomia, birth defects and impaired mental development in children.

Unfortunately, natural folates in food are characterised by low stability and are broken down under the influence of many factors, e.g. light, temperature, heat treatment and oxygen.

What is the difference between L-5-MTHF, folinic acid and folic acid?
Folic acid is a synthetic form. This compound is gradually reduced in the intestinal epithelium in the initial stage into dihydrofolate (DHF) and then into L-stereoisomer of tetrahydrofolate (THF). In next reactions with the activity of proper enzymes, this compound is converted into L-5-MTHF, which is the most reduced form.

L-5-MTHF (L-5-methyltetrahydrofolate) is a basic active form of reduced folates in serum. L-5-MTHF is involved actively in metabolic processes of folates and its activity is comparable to or even higher than folic acid. L-5-MTHF supplementation increases effectively folate levels in serum and erythrocytes and may be useful for both women planning pregnancy and pregnant and breastfeeding women.

Unlike folic acid, this form does not undergo reduction reactions in the presence of the enzyme DHFR and MTHFR before cellular metabolic processes of folates. The omission of these processes helps use the compound quickly and directly in cellular processes. Because of that, L-5-MTHF supplementation is helpful especially in genetically determined low activity of DHFR and MTHFR.

Like L-5-MTHF, folinic acid is one of the most active forms of folates and does not require enzymatic conversion. It is used mainly for reducing toxic activity of antagonists of folic acid. This substance is stable after isolation and is often used as a substitute for folic acid.

Folate deficiencies
Folate deficiencies are caused by, among other things, drinking too much alcohol, contraceptives and diet poor in leafy vegetables. This contributes to inhibiting regeneration and growth of cells in the body, chronic fatigue, problems with concentration and memory, anaemia, digestive disorders, insomnia and also states of anxiety.

Folate deficiencies in pregnancy may lead to defects of the central nervous system and placenta and abnormal development of brain functions. It may also cause miscarriages, preterm births and low birth weight in newborns.

Folates in pregnancy
Folates affect neuronal growth and proliferation and are also involved in the production of neurotransmitters – dopamine, noradrenaline, adrenaline and serotonin. Consequently, they are responsible for healthy functioning of the nervous system. It has been shown that inadequate folate intake during pregnancy contributes significantly to an increased incidence of neuropsychological disorders in children.

One of the worst consequences of folate deficiency is neural tube defects which affect more and more children. It is estimated that 1-2 cases of this disease are in every 1000 births. Inborn neural tube defects contribute to stopping the development of the brain and spinal cord which leads to anencephaly, spina bifida and encephalocele.

According to the latest studies, taking traditional folic acid may be not enough to prevent foetal neural tube defects. It is believed that every second woman may have impaired metabolism of folic acid. This may lead thus to malabsorption in the body and consequently an increased risk of foetal disorders.

Forms in this preparation do not require additional metabolism and can be used immediately by the body and that is why they are recommended to pregnant women.

Folates and methhylation
Methylation consists in the transfer of methyl group –CH3 between molecules and consequently addition of the group to an enzyme responsible for a particular biological function. Proper methylation reactions are necessary for, among other things, body detox, cellular growth and regeneration, formation of immune cells, DNA synthesis and healthy functioning of the nervous system.

It is assumed that problems with methylation, especially associated with the mutation of MTHFR may affect every second person. As a consequence, they may lead primarily to increasing levels of homocysteine which contributes to promoting inflammation and development of cardiovascular diseases, impaired synthesis of neurotransmitters and abnormal detoxification processes in the body.

Active forms of folates in the formula help avoid elaborated and often problematic metabolism, which ensures high bioavailability and maximum utilization in the body. They can be safely taken by individuals with a defective MTHFR gene in whom the supplementation with a traditional folic acid may cause many health problems.

To sum up, Seeking Health Active Folate is a dietary supplement which can be a safe and effective alternative for folic acid. The formula will work for individuals with MTHFR mutation and pregnant women. Due to high bioavailability and absorption it will perfectly make up deficiencies caused by inadequate nutrition.

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Active Folate Active Folate 60 lozenges
SEEKING HEALTH
18.31 $
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Active Folate 60 lozenges

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- Foreign shippment from 6.19 $ Every 93.08 $ reduces shipping costs by 3.10 $

- Delivery even day after tomorrow

You have got questions about the product

sales@mz-store.co.uk

01709231594 (mon.-fri 900-1700)

- Foreign shippment from 6.19 $ Every 93.08 $ reduces shipping costs by 3.10 $

- Delivery even day after tomorrow

You have got questions about the product

sales@mz-store.co.uk

01709231594 (mon.-fri 900-1700)

Description
  • Contains two bioactive forms of folates (!)
  • Promotes a healthy cardiovascular system
  • Helps stabilise homocysteine levels
  • Helps regulate nervous system function
  • Is involved in neurotransmitter synthesis
  • Strengthens memory and concentration                         
  • Supports a healthy foetal development
  • Improves cognitive functions
  • Improves methylation processes
  • Necessary for pregnant women
  • Helpful in anaemia

Seeking Health Active Folate is a dietary supplement with two active forms of folates characterised by direct bioavailability – Quatrefolic® L-5-methyltetrahydrofolate   and calcium folinate in the dose of 800 mcg per capsule.

Folates are a natural form of vitamin B9. They are found mainly in greens, broccoli, asparagus, avocado and whole grains. Adequate folate levels in the body prevent the incidence of hyperhomocysteinaemia, impaired synthesis of purines and pyrimidine as well as abnormal DNA methylation.

Normal metabolism of folates reduces the incidence of cardiovascular and neurological disorders. In the case of pregnant women, it decreases also the risk of such complications as miscarriage, macrosomia, birth defects and impaired mental development in children.

Unfortunately, natural folates in food are characterised by low stability and are broken down under the influence of many factors, e.g. light, temperature, heat treatment and oxygen.

What is the difference between L-5-MTHF, folinic acid and folic acid?
Folic acid is a synthetic form. This compound is gradually reduced in the intestinal epithelium in the initial stage into dihydrofolate (DHF) and then into L-stereoisomer of tetrahydrofolate (THF). In next reactions with the activity of proper enzymes, this compound is converted into L-5-MTHF, which is the most reduced form.

L-5-MTHF (L-5-methyltetrahydrofolate) is a basic active form of reduced folates in serum. L-5-MTHF is involved actively in metabolic processes of folates and its activity is comparable to or even higher than folic acid. L-5-MTHF supplementation increases effectively folate levels in serum and erythrocytes and may be useful for both women planning pregnancy and pregnant and breastfeeding women.

Unlike folic acid, this form does not undergo reduction reactions in the presence of the enzyme DHFR and MTHFR before cellular metabolic processes of folates. The omission of these processes helps use the compound quickly and directly in cellular processes. Because of that, L-5-MTHF supplementation is helpful especially in genetically determined low activity of DHFR and MTHFR.

Like L-5-MTHF, folinic acid is one of the most active forms of folates and does not require enzymatic conversion. It is used mainly for reducing toxic activity of antagonists of folic acid. This substance is stable after isolation and is often used as a substitute for folic acid.

Folate deficiencies
Folate deficiencies are caused by, among other things, drinking too much alcohol, contraceptives and diet poor in leafy vegetables. This contributes to inhibiting regeneration and growth of cells in the body, chronic fatigue, problems with concentration and memory, anaemia, digestive disorders, insomnia and also states of anxiety.

Folate deficiencies in pregnancy may lead to defects of the central nervous system and placenta and abnormal development of brain functions. It may also cause miscarriages, preterm births and low birth weight in newborns.

Folates in pregnancy
Folates affect neuronal growth and proliferation and are also involved in the production of neurotransmitters – dopamine, noradrenaline, adrenaline and serotonin. Consequently, they are responsible for healthy functioning of the nervous system. It has been shown that inadequate folate intake during pregnancy contributes significantly to an increased incidence of neuropsychological disorders in children.

One of the worst consequences of folate deficiency is neural tube defects which affect more and more children. It is estimated that 1-2 cases of this disease are in every 1000 births. Inborn neural tube defects contribute to stopping the development of the brain and spinal cord which leads to anencephaly, spina bifida and encephalocele.

According to the latest studies, taking traditional folic acid may be not enough to prevent foetal neural tube defects. It is believed that every second woman may have impaired metabolism of folic acid. This may lead thus to malabsorption in the body and consequently an increased risk of foetal disorders.

Forms in this preparation do not require additional metabolism and can be used immediately by the body and that is why they are recommended to pregnant women.

Folates and methhylation
Methylation consists in the transfer of methyl group –CH3 between molecules and consequently addition of the group to an enzyme responsible for a particular biological function. Proper methylation reactions are necessary for, among other things, body detox, cellular growth and regeneration, formation of immune cells, DNA synthesis and healthy functioning of the nervous system.

It is assumed that problems with methylation, especially associated with the mutation of MTHFR may affect every second person. As a consequence, they may lead primarily to increasing levels of homocysteine which contributes to promoting inflammation and development of cardiovascular diseases, impaired synthesis of neurotransmitters and abnormal detoxification processes in the body.

Active forms of folates in the formula help avoid elaborated and often problematic metabolism, which ensures high bioavailability and maximum utilization in the body. They can be safely taken by individuals with a defective MTHFR gene in whom the supplementation with a traditional folic acid may cause many health problems.

To sum up, Seeking Health Active Folate is a dietary supplement which can be a safe and effective alternative for folic acid. The formula will work for individuals with MTHFR mutation and pregnant women. Due to high bioavailability and absorption it will perfectly make up deficiencies caused by inadequate nutrition.

Directions for use
Manufacturer

Composition

Composition

Container size: 60 lozengesServing size: 1 lozengeServings per container: 60
per 1 lozengeamount%DV
Folate (50% as Quatrefolic® [(6S)-5-methyltetrahydrofolate, glucosamine salt] and 50% as calcium folinate)800 mcg DFE200%

Other ingrednients

Xylitol, ascorbyl palmitate, natural cherry flavor, and silica.
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