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  • RAW SERIES SAMe 50g
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SAMe SAMe

RAW SERIES SAMe provides S-adenosyl methionine, which is the main methyl group donor for many metabolic reactions in the organism. It is an extremely versatile supplement, whose most powerful activity focuses on the health of the nervous system, bones and joints, and mental processes.

S-adenosyl methionine is thought to be the most important substrate in the methylation process in the organism. It is responsible for providing methyl groups in many chemical reactions. It also makes two other components extremely important for normal methylation bioavailable, that is folic acid and cobalamin. SAMe attaches to methionine formed under the influence of folic acid and vitamin B12 methylated from homocysteine, creating S-andenosyl homocysteine, which enables the smooth process of the methylation cycle.

Enhancing methylation should constitute a key aspect of creating a supplementation plan because tests demonstrate that already over half of society has problems with the functioning of the process. The genesis of methylation disorders is believed to be the high level of food processing; however, it has been observed that more and more people have a mutation of the gene MTHFR, which is a methylation regulator.

Health of the nervous system
The greatest benefits of SAMe supplementation can be observed in terms of the nervous system. S-adenosyl methionine has been demonstrated to have both neuroprotective and therapeutic effects on mental dysfunctions, as it affects the way the precursor of one of the most crucial neurotransmitters circulates, that is acetylcholine. Because of its ability to cross the blood-brain barrier, SAMe stimulates the conversion of nicotinamide to N-methyl-nicotinamide, which inhibits the removal of choline (acetylcholine precursor) from the tissues of the nervous system.

The above-described mechanism is extremely important for the regulation of the mood. Tests demonstrate that SAMe supplementation translates into an improvement of the mood in mentally healthy people. Even more spectacular effects can be obtained in people with emotional problems, especially depressive disorders. That is where S-adenosyl methionine is referred to as an extremely efficient and at the same time a safe method of therapy.

The application of SAMe in neurodegenerative disease treatment is just as efficient. Scientific studies show a significant improvement of the condition of patients who suffer from Alzheimer’s disease, Parkinson’s disease, or even multiple sclerosis. The effects are connected with S-adenosyl methionine’s ability to increase the level of the extracellular enzyme catechol-o-methyltransferase, whose too low levels distort catecholamine metabolism, which has a toxic effect on nerve cells.

Tests also show the benefits of using SAMe by healthy people, and not only for neuroprotective purposes. Regular supplementation helps to increase the concentration of phosphocreatine and reduce beta-nucleoside levels, which results in an improvement in cognitive functions.

Therapeutic effect on bones and joints
S-adenosyl methionine constitutes complex support for the musculoskeletal system as well. It helps to increase the density of cartilage tissue by stimulating the synthesis of proteoglycans – the structural proteins of joint cartilage. Moreover, it has an important therapeutic effect in fibromyalgia. It is one of the most efficient forms of treating rheumatic pains as a safer alternative for popular non-steroid anti-inflammatory drugs with the same power of activity. S-adenosyl methionine also exhibits the ability to reduce pain in inflammatory bone and joint diseases.

Oxidative stress reduction
SAMe is also able to stimulate significantly the synthesis of glutathione (GSH), which translates into its higher levels both in peripheral blood (by increasing saturation of erythrocytes) and in the tissues that form crucial organs. In this case, it is about the two organs above all that are especially susceptible to the increase of GSH levels: the brain and the liver. In the former, glutathione prevents the neurotoxic activity of free radicals, that way strengthening the neuroprotective effect of SAMe. In the liver, on the other hand, it has a detoxifying effect, and the reduction of oxidative stress influenced by GSH allows the extremely important organ to regenerate more efficiently.

Increasing glutathione levels in the entire body brings a number of benefits resulting from the complete reduction of the number of free radicals; the benefits can be a delay in aging processes, increased mitochondria efficacy, or a reduced risk of developing a neoplastic disease. As a strong antioxidant, GSH prevents genetic mutations and enables normal and smooth gene expression in cells.

Support for the circulatory system
S-adenosyl methionine supplementation has an effect on the health of the cardiovascular system as well. By participating in homocysteine transformations, it facilitates its neutralisation, which reduces the risk of blood vessel damage, that is the main reason of developing atherosclerosis. Tests also demonstrate the ability of SAMe to regulate blood pressure and to improve blood flow in people who struggle with decreased local circulation.

Inflammation reduction
S-adenosyl methionine also exhibits immunostimulatory abilities by affecting the level of the cytokines TNF-α and interleukin 1. They are the proteins that stimulate inflammatory processes in the organism and the formation of acute-phase proteins. SAMe works as their inhibitor, which results in a reduction of inflammations in the organism.

To sum up, RAW SERIES SAMe is a supplement supplying one of the most desired compounds in the organism, a substance which is a substrate in many reactions crucial for the normal functioning of every system. Considering the versatility of S-adenosyl methionine’s effects, a vast majority of people will notice the benefits of using it. SAMe should be of particular interest to people who struggle with mental disorders or distorted methylation processes (including disorders resulting from MTHFR gene mutation).

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SAMe SAMe 50g
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SAMe 50g

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Products from our warehouse in the United Kingdom we ship to the following countries and locations:

ZONE 1: England, Wales and Scotland (excluding Highlands and Islands)

ZONE 2: Northern Ireland, Highlands, Isles of Scottland, Isle of Man, Isles of Scilly, Guernsey (GY) and Jersey (JE) 



ZONE 3: Irish Republic



Shippings to the above mentioned countries are also carried out from our warehouses located in the European Union, but they may involve additional costs and customs procedures.

EU Stock Available

Products from our warehouses located in the European Union we ship to all its member countries. As well as to Norway, Switzerland, Iceland or the United Kingdom, as well as to the USA, Canada, Japan, Australia or to the Middle East, but it may involve additional costs and customs procedures.

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Description
  • Source of S-adenosyl methionine, main methyl group donor in organism
  • Therapeutic effect on mental disorders
  • Reduces pain connected with rheumatoid lesions
  • Supports functioning of cardiovascular system
  • Stimulates synthesis of strong antioxidant – glutathione
  • Supports liver detoxification and regeneration
  • Complex support for methylation processes
  • Supports cartilage tissue regeneration
  • Regulates concentration of pro-inflammatory cytokines
  • Able to improve well-being
  • Exhibits neuroprotective effect

RAW SERIES SAMe provides S-adenosyl methionine, which is the main methyl group donor for many metabolic reactions in the organism. It is an extremely versatile supplement, whose most powerful activity focuses on the health of the nervous system, bones and joints, and mental processes.

S-adenosyl methionine is thought to be the most important substrate in the methylation process in the organism. It is responsible for providing methyl groups in many chemical reactions. It also makes two other components extremely important for normal methylation bioavailable, that is folic acid and cobalamin. SAMe attaches to methionine formed under the influence of folic acid and vitamin B12 methylated from homocysteine, creating S-andenosyl homocysteine, which enables the smooth process of the methylation cycle.

Enhancing methylation should constitute a key aspect of creating a supplementation plan because tests demonstrate that already over half of society has problems with the functioning of the process. The genesis of methylation disorders is believed to be the high level of food processing; however, it has been observed that more and more people have a mutation of the gene MTHFR, which is a methylation regulator.

Health of the nervous system
The greatest benefits of SAMe supplementation can be observed in terms of the nervous system. S-adenosyl methionine has been demonstrated to have both neuroprotective and therapeutic effects on mental dysfunctions, as it affects the way the precursor of one of the most crucial neurotransmitters circulates, that is acetylcholine. Because of its ability to cross the blood-brain barrier, SAMe stimulates the conversion of nicotinamide to N-methyl-nicotinamide, which inhibits the removal of choline (acetylcholine precursor) from the tissues of the nervous system.

The above-described mechanism is extremely important for the regulation of the mood. Tests demonstrate that SAMe supplementation translates into an improvement of the mood in mentally healthy people. Even more spectacular effects can be obtained in people with emotional problems, especially depressive disorders. That is where S-adenosyl methionine is referred to as an extremely efficient and at the same time a safe method of therapy.

The application of SAMe in neurodegenerative disease treatment is just as efficient. Scientific studies show a significant improvement of the condition of patients who suffer from Alzheimer’s disease, Parkinson’s disease, or even multiple sclerosis. The effects are connected with S-adenosyl methionine’s ability to increase the level of the extracellular enzyme catechol-o-methyltransferase, whose too low levels distort catecholamine metabolism, which has a toxic effect on nerve cells.

Tests also show the benefits of using SAMe by healthy people, and not only for neuroprotective purposes. Regular supplementation helps to increase the concentration of phosphocreatine and reduce beta-nucleoside levels, which results in an improvement in cognitive functions.

Therapeutic effect on bones and joints
S-adenosyl methionine constitutes complex support for the musculoskeletal system as well. It helps to increase the density of cartilage tissue by stimulating the synthesis of proteoglycans – the structural proteins of joint cartilage. Moreover, it has an important therapeutic effect in fibromyalgia. It is one of the most efficient forms of treating rheumatic pains as a safer alternative for popular non-steroid anti-inflammatory drugs with the same power of activity. S-adenosyl methionine also exhibits the ability to reduce pain in inflammatory bone and joint diseases.

Oxidative stress reduction
SAMe is also able to stimulate significantly the synthesis of glutathione (GSH), which translates into its higher levels both in peripheral blood (by increasing saturation of erythrocytes) and in the tissues that form crucial organs. In this case, it is about the two organs above all that are especially susceptible to the increase of GSH levels: the brain and the liver. In the former, glutathione prevents the neurotoxic activity of free radicals, that way strengthening the neuroprotective effect of SAMe. In the liver, on the other hand, it has a detoxifying effect, and the reduction of oxidative stress influenced by GSH allows the extremely important organ to regenerate more efficiently.

Increasing glutathione levels in the entire body brings a number of benefits resulting from the complete reduction of the number of free radicals; the benefits can be a delay in aging processes, increased mitochondria efficacy, or a reduced risk of developing a neoplastic disease. As a strong antioxidant, GSH prevents genetic mutations and enables normal and smooth gene expression in cells.

Support for the circulatory system
S-adenosyl methionine supplementation has an effect on the health of the cardiovascular system as well. By participating in homocysteine transformations, it facilitates its neutralisation, which reduces the risk of blood vessel damage, that is the main reason of developing atherosclerosis. Tests also demonstrate the ability of SAMe to regulate blood pressure and to improve blood flow in people who struggle with decreased local circulation.

Inflammation reduction
S-adenosyl methionine also exhibits immunostimulatory abilities by affecting the level of the cytokines TNF-α and interleukin 1. They are the proteins that stimulate inflammatory processes in the organism and the formation of acute-phase proteins. SAMe works as their inhibitor, which results in a reduction of inflammations in the organism.

To sum up, RAW SERIES SAMe is a supplement supplying one of the most desired compounds in the organism, a substance which is a substrate in many reactions crucial for the normal functioning of every system. Considering the versatility of S-adenosyl methionine’s effects, a vast majority of people will notice the benefits of using it. SAMe should be of particular interest to people who struggle with mental disorders or distorted methylation processes (including disorders resulting from MTHFR gene mutation).

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Composition

Composition

Container size: 50gServing size: 400mgServings per container: 125
per 1 portionamount%DV
S-Adenosyl Methionine400 mg-

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