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  • REVANGE Knock Out PM 30 kaps.
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Since 2005  sales@mz-store.co.uk  7767803657
Knock Out PM Knock Out PM
Revange Knock Out PM Night GH formula is an effective formulation facilitatig falling asleep, improving sleep quality and night regeneration of the system. Through multidirectional action it calms and relaxes the body, creates a sense of well-being.

Facilitating a development of the nervous system and its functioning, it supports the creation of memory. In addition, by engaging in the work of a hormone economy, especially by strengthening ejection of a growth hormone, it improves night regeneration system, favoring the renewal of muscles and losing excessive body fat tissue.

The product Revenge Knock Out PM Night GH formula includes:

Phenibut – phenolic compound structurally similar to the acid gamma-aminobutyric acid (GABA), whose effectiveness was appreciated by astronauts involved in spaceflights. By acting as a full agonist of GABA B receptor, and also in larger quantities GABA A, it affects the nervous system via GABA-mimetic. By lowering a degree of neuronal excitability, it calms the body. By increasing the activity of dopamine receptors, it promotes a feeling of well-being and hapiness.
It reduces the level of stress. By calming the system, reducing stress, affectinf temperature reduction and muscle relaxation, it promotes regularity of the process of falling asleep. It promotes the creation of a positive attitude to life the next day. By counteracting neurodegeneration of the nervous system, it supports nerve conduction and memory processes. By intensifying the secretion of growth hormone, it accelerates night renewal system and a decomposition and burning of excessive body fat.

Gamma-aminobutyric acid (GABA) – endogenously produced inhibitory neurotransmitter, which is synthesized in the nervous system of glutamate with a participation of glutamate decarboxylase. With affinity for GABA A receptor, it stimulates a transport of chloride ions into the cell, leading to hipelpolarization of a membrane, what makes a nerve conduction difficult.
By interacting with GABA B receptors, it reduces a rate of production of excitatory neurotransmitters. Thanks to its properties, it inhibits the nerve conduction. By muting the system and reducing nervous tension, it calms the body, reduces anxiety and promotes better sleep. By interfering with the nerve conduction, it reduces the intensity of pain.
By regulating the growth of embryos and neuronal stem cells, proliferation, migration and differentiation of neural cells and neurite extension and synapse formation, it affects a development of the brain and the rest of the nervous system. By raising a level of growth hormone in the body, it supports the process of its recovery and growth, and reduces fat storage.

The extract of Mucuna pruriens – the extract from selected parts, usually seeds, of subshrubs called a proper scabies in Poland, a planta classified to the Fabaceae family, growing in Africa, tropical parts of Asia and the Pacific islands. Its specific properties are the result of a high content of levodopa (L-DOPA), catechol amine, which is derived from tyrosine. L-DOPA acting as a dopamine precursor, a neurotransmitter engaging in the functioning of the dopaminergic system, it prevents the occurrence of depression and discouragement, promoting the creation of a general feeling of well-being.
By wealth of antioxidant substances, L-dopa and the effect of the regulation of mitochondrions work, it improves the effectiveness of the antioxidant barrier. By counteracting oxidative damages, it reduces stress-induced neuronal degeneration and supports maintaining a good health of the cardiovascular system. I thas anti-inflammatory and anit-fever properties. By showing insulin-mimetic properties, it lowers blood sugar level. By helping the secretion of testosterone and growth hormone, it supports overlap of regenerative processes in the body and promotes the maintenance of a proper body composition. It increases libido in the case of men.

5-hydroxytryptophan (5-HTP) – a naturally synthesized in the human body amino acid, which is formed from L-tryptophan with a participation of tryptophan hydroxylase. Thanks to its abilities of the smooth crossing the blood-brain barrier and the lack of feedback inhibition of the product reaction, it is present as an effective precursor of serotonin. It supports muting and relaxing the body.
It preventa panic attacks. By increasing the availability of a direct precursor of a sleep hormone (melatonin), it supports the process of falling asleep. It reduces pain, stiffness of the body, anxiety and fatigue occurring after a bad night's sleep. By reducing an appetite, and a desire to consume carbohydrate and snacking between meals, it supports the maintenance of optimal body weight.

Picamilon – a substance being a result of combining gamma-aminobutyric acid (GABA) and niacin, whose effectiveness is primarily due to the ability to crossing the blood-brain barrier. By affecting the activity of GABA receptors and reducing central nervous system stimulant properties of glutamate, it mutes the system.
By lowering the level of cortisol, it prepares the body to take a peaceful night rest and provides a relaxed attitude the next day. By promoting relaxation of vascular smooth muscles, which leads to better oxygenation, nutrition and detoxification of the body and increasing the secretion of growth hormone, it enhances the body's night-time renewal and regeneration of damaged structures.
By intensifying growth hormone release, it accelerates the breakdown of fat storage and prevents the re-accumulation. By limiting the accumulation of fat reserves, normalizing the lipid profile and increasing adiponectin concentration, it improves the condition of the circulatory system.

The extract of valerian – the essence obtained from products based on roots of Valeriana L., the type of species collective perennials belonging to the family Caprifoliaceae, plants growing on damp and shaded areas of Asia, Europe and North America. Its mechanism of action is based primarily on the ability to promote ejection GABA and blocking the activity of enzymes digesting it, which prolongs their excitability and significantly interferes with the operation of the GABA system.
By stimulating the opening of chloride channels and associated with it influx of chloride ions inside neurons, it decreases its activity throughout the excitability of the nervous system, leading to its muting. By stimulating the secretion of the sleep hormone (melatonin), it promotes processes allowing falling asleep and have a high-quality sleep.
By lowering an activity of beta brainwaves, while strengthening delta and theta, it supports a peaceful sleep. Its properties muting system, some of the valerian compounds also exhibit an affinity for A1 adenosine receptors.

A hops extract - the extract from the resin inflorescences of hops, winding vines which belongs to the family Cannabaceae, growing wild in the northern hemisphere in the southern countries of Europe, the Middle East and America, widely cultivated in temperate climate regions of Europe and Asia. By increasing the efficiency of the activity of the neurotransmitter GABA, by modulationa assigned GABA A receptors located in the brain, it reduces the excitability of the nervous system, muting it.
By affecting the activity of serotonin, it supports a creation of melatonin, a hormone necessary to regulate the circadian rhythm. By acting on adenosine receptors, it supports signal about a need to rest. By blocking the receptors M3 muscarinic, histamine H1 and 5-HT, stimulating the synthesis of nitric oxide, affecting systems: purinergic, adrenergic and GABA, it promotes a relaxation of smooth muscles of intestines, by slowing down the digestive system being prepared to sleep.
By inhibiting the excitability of the nervous system, it shows analgesic properties. By operating as antioxidant, it improves the efficiency of antioxidant barrier. By supporting bone metabolism, is conducive to maintaining good bone health. By demonstrating properties of immunomodulator, it increases the level of leukocytes and T-lymphocyte subpopulations.

L-theanine – a derivative of glutamine, a not proteolytic amino acid, which is an important source of Camellia sinensis, a plant growing on the warmer parts of Asia, classified to the family Theaceae, which leaves is used to produce a hot drink called tea, valued especially in Japan and England. L-theanine increases GABA level, initiates slowing down nerve conduction hyperpolarization of the membrane of neurons and reduces the synthesis of excitatory neurotransmitters.
By blocking the receptors of glutamic acid and abolishing the psychostimulant effects of caffeine, it creates an environment conducive to mute the system. By inducing brain-derived neurotrophic factor (BDNF) in hipokambie, leading to increase synthesis of dopamine, as well as acting as N-methyl-D-aspartate (NMDA) agonist, it prevents apathy, helps to improve mood and well-being.

Sulbutiamine – a synthetic analogue of vitamin B1, a compound being a combination of two molecules of thiamine. Thanks to a more lipophilic character, it increase bioavailability and big easiness in crossing a blood-brain barrier, which increases the performance for the individual molecules of thiamine. By increasing the uptake of choline, increasing activity of glutamate and intensifying cholinergic activity in the hippocampus, it supports memory processes.
By intensifying the activity of glutathione transferase and raising the level of reduced glutathione, it improves antioxidant barrier, especially of the nervous system. By improving energy metabolism and stimulating the electrophysiological properties of neuronal synaptic transmission, it shows a neuroprotective effect. By affecting the cholinergic system, it supports the brain-muscle connection. It reduces fatigue and helps to reduce erectile dysfunction.

Melatonin – emerging in the largest quantities in the pineal gland indoloamina pinealocytes, naturally synthesized using N-acetylserotonin created previously from serotonin. Its characteristics it manifests by interacting with MT1, MT2 and MT3 melatonin and nuclear receptors. By affecting the operation of the biological clock, it regulates processes occurring both in the diurnal cycle, as long-term, eg. annually. It gives the body a signal to sleep.
By preparing the system for the night's rest, it reduces the temperature of the body, lowers blood pressure, slows digestion and adjusts the rate of biochemical changes. It improves mood and attitude to life after a good night's sleep. I has a significant impact on the ejection of hormones of the hypothalamus, pituitary and gonads, particularly follicle stimulating (FSH) and luteinizing (LH) hormone, what is reflected in the normalization of reproductive performance.
By reducing the expression of ERa, inhibiting the association of  estradiol ER complex with ERE spot to DNA and reducing aromatase activity, it exhibits anti-estrogen properties. By optimizing growth hormone and cortisol levela, it improves night renewal system, a growth of desired structures and burning of excessive body fat. By intensifying the expression of glutathione peroxidase, superoxide dismutase and catalase, reducing the excitability of nitric oxide synthase, promoting the synthesis of glutathione and deactivating singlet oxygen, hydroxyl radical and hydrogen peroxide, it exhibits antioxidant properties.
By improving an activity and blocking an excessive apoptosis of immune cells, normalizing a production of IL-2, IL-6, IL-12 interleukins, it supports the immune system. By acting as an antioxidant, reducing blood pressure and cholesterol level, it helps maintain good health of the cardiovascular system. By regulating the cell cycle, increasing antioxidant barrier, improving the work of the immune system, it prevents processes of carcinogenesis.

Piperine – an alkaloid responsible for specific, burning taste of black pepper fruits (Piper nigrum), a long-lived plant which belongs to the family Piperaceae, vining shrub growing on the tropical regions of India. By increasing an inflow of gastric acid and proteolytic enzymes, it facilitates a process of protein degradation in the gastrointestinal tract.
By increasing an accumulation of blood in intestines, it improves an absorption of amino acids, carbohydrates, vitamins, with an emphasis on B-vitamins; minerals, and other nutrients, such as curcumin, resveratrol, or Q10 coenzyme. By mobilizing the input of components to cells, it improves their efficiency. By revealing antioxidant properties and reduces oxidative stress.
By reducing a level of prostaglandin E2 (PGE2) and interleukin-6 (IL 6), it limits the amount of inflammations and shows an analgesic effect. By engaging in the functioning of the serotonergic system, it promotes relaxation and calms the body. By stimulating MC-4 receptors, thereby affecting the level of apolipoprotein and the activity of lipoprotein lipase and lecithin: cholesterol acyltransferase, it reduces the level of triglycerides, total cholesterol, LDL and VLDL and increases the level of HDL, thereby it normalizes the lipid profile.
By optimizing the lipid profile and showing antioxidant and anti-inflammatory properties, it  supports maintaining good cardiovascular health. By interfering in the level of thyroid hormones, in particular T3 and T4, and increasing the concentration of cAMP, it improves carbohydrate-lipid economy. By minimizing the activity of MMP13 collagenase, it reduces collagen degradation, thereby contributing to maintaining good joint condition and attractive appearance of the skin.

Galantamine – a tertiary alkaloid that occurs naturally in the tubers of Caucasian snowdrop, a multiannual, thriving green plant of the family Amaryllidaceae, occurring in the Caucasus and in the north-western Iran. By being a specific, competitive and reversible inhibitor of acetylcholinesterase, it prevents the degradation of acetylcholine. By intensifying the response of nicotinic receptors, it increases the release of acetylcholine from presynaptic nerve endings. By engaging in the operation of the cholinergic system, it contributes to improvement of cognitive functions and memory.

Revange Knock Out PM Night GH formula is a product preparing the body to an fficiently night rest. By increasing the concentration of muting neurotransmitters and interfering with the activity of systems: GABA, cholinergic, serotonergic or dopaminergic; it reduces neuronal excitability, reassuring system, through which it supports the process of falling asleep, ensuring high quality sleep.
By reducing a level of stress, anxiety and uncertainty, it gives a sense of well-being, relaxation and allows to create a positive attitude towards the next day. By interfering in cell growth, differentiation, proliferation and development of neurons, improving glucose metabolism in the brain and stimulating the electrophysiological properties of neurons, it improves the development and functioning of the nervous system. By engaging in the work of the cholinergic system, it supports memory processes and a memory formation.
By supporting the endocrine system, mainly through increasing the secretion of growth hormone, it improves the renewal of body structures. It supports the regeneration of muscle and bone tissue and accelerates the decomposition and burning of excessive body fat. Furthermore, by revealing antioxidant and anti-inflammatory properties, it increases the effectiveness of the antioxidant barrier and reduces damages to the circulatory system and many organs. Revenge Knock Out PM is an exceptional preparation, effectively increasing the joy of life after a solid sleep.

UK Stock
5 3
4

Szczerze powiedziawszy średnio - po wzięciu nie zauważyłem większej senności, przy zaśnięciu niezbyt pomaga. Sen natomiast bardzo mocny, faktycznie ponad 8 godzin, trudno się dobudzić. Będę stosował w dni wolne żeby się wyspać, niestety na codzień się nie nadaje
5

Super preparat. Mocny spokojny sen. Uwaga 8-10 godz snu gwarantowane.
5

Sen 100 razy lepszy!!! melatonina czy gaba moga sie schowac!
Since 2005
Knock Out PM Knock Out PM 30 caps.
REVANGE
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Knock Out PM 30 caps.

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Description
  • Increases the concentration of GABA
  • Intensifies the effects of melatonin
  • Slows neuronal excitability
  • Promotes a sense of well-being
  • Reduces a fear feeling
  • Supports muting the system
  • Promotes falling asleep
  • Improves the quality of sleep
  • Creates a positive attitude to life
  • Supports the development of the nervous system
  • Improves the process of memory formation
  • Enhances secretion of growth hormone
  • Increases the rate of recovery of the body
  • Accelerates muscle recovery
  • Promotes loss of excess body fat
  • Strengthens the antioxidant barrier
  • Limits the amount of inflammations
  • Improves immune system functioning
Revange Knock Out PM Night GH formula is an effective formulation facilitatig falling asleep, improving sleep quality and night regeneration of the system. Through multidirectional action it calms and relaxes the body, creates a sense of well-being.

Facilitating a development of the nervous system and its functioning, it supports the creation of memory. In addition, by engaging in the work of a hormone economy, especially by strengthening ejection of a growth hormone, it improves night regeneration system, favoring the renewal of muscles and losing excessive body fat tissue.

The product Revenge Knock Out PM Night GH formula includes:

Phenibut – phenolic compound structurally similar to the acid gamma-aminobutyric acid (GABA), whose effectiveness was appreciated by astronauts involved in spaceflights. By acting as a full agonist of GABA B receptor, and also in larger quantities GABA A, it affects the nervous system via GABA-mimetic. By lowering a degree of neuronal excitability, it calms the body. By increasing the activity of dopamine receptors, it promotes a feeling of well-being and hapiness.
It reduces the level of stress. By calming the system, reducing stress, affectinf temperature reduction and muscle relaxation, it promotes regularity of the process of falling asleep. It promotes the creation of a positive attitude to life the next day. By counteracting neurodegeneration of the nervous system, it supports nerve conduction and memory processes. By intensifying the secretion of growth hormone, it accelerates night renewal system and a decomposition and burning of excessive body fat.

Gamma-aminobutyric acid (GABA) – endogenously produced inhibitory neurotransmitter, which is synthesized in the nervous system of glutamate with a participation of glutamate decarboxylase. With affinity for GABA A receptor, it stimulates a transport of chloride ions into the cell, leading to hipelpolarization of a membrane, what makes a nerve conduction difficult.
By interacting with GABA B receptors, it reduces a rate of production of excitatory neurotransmitters. Thanks to its properties, it inhibits the nerve conduction. By muting the system and reducing nervous tension, it calms the body, reduces anxiety and promotes better sleep. By interfering with the nerve conduction, it reduces the intensity of pain.
By regulating the growth of embryos and neuronal stem cells, proliferation, migration and differentiation of neural cells and neurite extension and synapse formation, it affects a development of the brain and the rest of the nervous system. By raising a level of growth hormone in the body, it supports the process of its recovery and growth, and reduces fat storage.

The extract of Mucuna pruriens – the extract from selected parts, usually seeds, of subshrubs called a proper scabies in Poland, a planta classified to the Fabaceae family, growing in Africa, tropical parts of Asia and the Pacific islands. Its specific properties are the result of a high content of levodopa (L-DOPA), catechol amine, which is derived from tyrosine. L-DOPA acting as a dopamine precursor, a neurotransmitter engaging in the functioning of the dopaminergic system, it prevents the occurrence of depression and discouragement, promoting the creation of a general feeling of well-being.
By wealth of antioxidant substances, L-dopa and the effect of the regulation of mitochondrions work, it improves the effectiveness of the antioxidant barrier. By counteracting oxidative damages, it reduces stress-induced neuronal degeneration and supports maintaining a good health of the cardiovascular system. I thas anti-inflammatory and anit-fever properties. By showing insulin-mimetic properties, it lowers blood sugar level. By helping the secretion of testosterone and growth hormone, it supports overlap of regenerative processes in the body and promotes the maintenance of a proper body composition. It increases libido in the case of men.

5-hydroxytryptophan (5-HTP) – a naturally synthesized in the human body amino acid, which is formed from L-tryptophan with a participation of tryptophan hydroxylase. Thanks to its abilities of the smooth crossing the blood-brain barrier and the lack of feedback inhibition of the product reaction, it is present as an effective precursor of serotonin. It supports muting and relaxing the body.
It preventa panic attacks. By increasing the availability of a direct precursor of a sleep hormone (melatonin), it supports the process of falling asleep. It reduces pain, stiffness of the body, anxiety and fatigue occurring after a bad night's sleep. By reducing an appetite, and a desire to consume carbohydrate and snacking between meals, it supports the maintenance of optimal body weight.

Picamilon – a substance being a result of combining gamma-aminobutyric acid (GABA) and niacin, whose effectiveness is primarily due to the ability to crossing the blood-brain barrier. By affecting the activity of GABA receptors and reducing central nervous system stimulant properties of glutamate, it mutes the system.
By lowering the level of cortisol, it prepares the body to take a peaceful night rest and provides a relaxed attitude the next day. By promoting relaxation of vascular smooth muscles, which leads to better oxygenation, nutrition and detoxification of the body and increasing the secretion of growth hormone, it enhances the body's night-time renewal and regeneration of damaged structures.
By intensifying growth hormone release, it accelerates the breakdown of fat storage and prevents the re-accumulation. By limiting the accumulation of fat reserves, normalizing the lipid profile and increasing adiponectin concentration, it improves the condition of the circulatory system.

The extract of valerian – the essence obtained from products based on roots of Valeriana L., the type of species collective perennials belonging to the family Caprifoliaceae, plants growing on damp and shaded areas of Asia, Europe and North America. Its mechanism of action is based primarily on the ability to promote ejection GABA and blocking the activity of enzymes digesting it, which prolongs their excitability and significantly interferes with the operation of the GABA system.
By stimulating the opening of chloride channels and associated with it influx of chloride ions inside neurons, it decreases its activity throughout the excitability of the nervous system, leading to its muting. By stimulating the secretion of the sleep hormone (melatonin), it promotes processes allowing falling asleep and have a high-quality sleep.
By lowering an activity of beta brainwaves, while strengthening delta and theta, it supports a peaceful sleep. Its properties muting system, some of the valerian compounds also exhibit an affinity for A1 adenosine receptors.

A hops extract - the extract from the resin inflorescences of hops, winding vines which belongs to the family Cannabaceae, growing wild in the northern hemisphere in the southern countries of Europe, the Middle East and America, widely cultivated in temperate climate regions of Europe and Asia. By increasing the efficiency of the activity of the neurotransmitter GABA, by modulationa assigned GABA A receptors located in the brain, it reduces the excitability of the nervous system, muting it.
By affecting the activity of serotonin, it supports a creation of melatonin, a hormone necessary to regulate the circadian rhythm. By acting on adenosine receptors, it supports signal about a need to rest. By blocking the receptors M3 muscarinic, histamine H1 and 5-HT, stimulating the synthesis of nitric oxide, affecting systems: purinergic, adrenergic and GABA, it promotes a relaxation of smooth muscles of intestines, by slowing down the digestive system being prepared to sleep.
By inhibiting the excitability of the nervous system, it shows analgesic properties. By operating as antioxidant, it improves the efficiency of antioxidant barrier. By supporting bone metabolism, is conducive to maintaining good bone health. By demonstrating properties of immunomodulator, it increases the level of leukocytes and T-lymphocyte subpopulations.

L-theanine – a derivative of glutamine, a not proteolytic amino acid, which is an important source of Camellia sinensis, a plant growing on the warmer parts of Asia, classified to the family Theaceae, which leaves is used to produce a hot drink called tea, valued especially in Japan and England. L-theanine increases GABA level, initiates slowing down nerve conduction hyperpolarization of the membrane of neurons and reduces the synthesis of excitatory neurotransmitters.
By blocking the receptors of glutamic acid and abolishing the psychostimulant effects of caffeine, it creates an environment conducive to mute the system. By inducing brain-derived neurotrophic factor (BDNF) in hipokambie, leading to increase synthesis of dopamine, as well as acting as N-methyl-D-aspartate (NMDA) agonist, it prevents apathy, helps to improve mood and well-being.

Sulbutiamine – a synthetic analogue of vitamin B1, a compound being a combination of two molecules of thiamine. Thanks to a more lipophilic character, it increase bioavailability and big easiness in crossing a blood-brain barrier, which increases the performance for the individual molecules of thiamine. By increasing the uptake of choline, increasing activity of glutamate and intensifying cholinergic activity in the hippocampus, it supports memory processes.
By intensifying the activity of glutathione transferase and raising the level of reduced glutathione, it improves antioxidant barrier, especially of the nervous system. By improving energy metabolism and stimulating the electrophysiological properties of neuronal synaptic transmission, it shows a neuroprotective effect. By affecting the cholinergic system, it supports the brain-muscle connection. It reduces fatigue and helps to reduce erectile dysfunction.

Melatonin – emerging in the largest quantities in the pineal gland indoloamina pinealocytes, naturally synthesized using N-acetylserotonin created previously from serotonin. Its characteristics it manifests by interacting with MT1, MT2 and MT3 melatonin and nuclear receptors. By affecting the operation of the biological clock, it regulates processes occurring both in the diurnal cycle, as long-term, eg. annually. It gives the body a signal to sleep.
By preparing the system for the night's rest, it reduces the temperature of the body, lowers blood pressure, slows digestion and adjusts the rate of biochemical changes. It improves mood and attitude to life after a good night's sleep. I has a significant impact on the ejection of hormones of the hypothalamus, pituitary and gonads, particularly follicle stimulating (FSH) and luteinizing (LH) hormone, what is reflected in the normalization of reproductive performance.
By reducing the expression of ERa, inhibiting the association of  estradiol ER complex with ERE spot to DNA and reducing aromatase activity, it exhibits anti-estrogen properties. By optimizing growth hormone and cortisol levela, it improves night renewal system, a growth of desired structures and burning of excessive body fat. By intensifying the expression of glutathione peroxidase, superoxide dismutase and catalase, reducing the excitability of nitric oxide synthase, promoting the synthesis of glutathione and deactivating singlet oxygen, hydroxyl radical and hydrogen peroxide, it exhibits antioxidant properties.
By improving an activity and blocking an excessive apoptosis of immune cells, normalizing a production of IL-2, IL-6, IL-12 interleukins, it supports the immune system. By acting as an antioxidant, reducing blood pressure and cholesterol level, it helps maintain good health of the cardiovascular system. By regulating the cell cycle, increasing antioxidant barrier, improving the work of the immune system, it prevents processes of carcinogenesis.

Piperine – an alkaloid responsible for specific, burning taste of black pepper fruits (Piper nigrum), a long-lived plant which belongs to the family Piperaceae, vining shrub growing on the tropical regions of India. By increasing an inflow of gastric acid and proteolytic enzymes, it facilitates a process of protein degradation in the gastrointestinal tract.
By increasing an accumulation of blood in intestines, it improves an absorption of amino acids, carbohydrates, vitamins, with an emphasis on B-vitamins; minerals, and other nutrients, such as curcumin, resveratrol, or Q10 coenzyme. By mobilizing the input of components to cells, it improves their efficiency. By revealing antioxidant properties and reduces oxidative stress.
By reducing a level of prostaglandin E2 (PGE2) and interleukin-6 (IL 6), it limits the amount of inflammations and shows an analgesic effect. By engaging in the functioning of the serotonergic system, it promotes relaxation and calms the body. By stimulating MC-4 receptors, thereby affecting the level of apolipoprotein and the activity of lipoprotein lipase and lecithin: cholesterol acyltransferase, it reduces the level of triglycerides, total cholesterol, LDL and VLDL and increases the level of HDL, thereby it normalizes the lipid profile.
By optimizing the lipid profile and showing antioxidant and anti-inflammatory properties, it  supports maintaining good cardiovascular health. By interfering in the level of thyroid hormones, in particular T3 and T4, and increasing the concentration of cAMP, it improves carbohydrate-lipid economy. By minimizing the activity of MMP13 collagenase, it reduces collagen degradation, thereby contributing to maintaining good joint condition and attractive appearance of the skin.

Galantamine – a tertiary alkaloid that occurs naturally in the tubers of Caucasian snowdrop, a multiannual, thriving green plant of the family Amaryllidaceae, occurring in the Caucasus and in the north-western Iran. By being a specific, competitive and reversible inhibitor of acetylcholinesterase, it prevents the degradation of acetylcholine. By intensifying the response of nicotinic receptors, it increases the release of acetylcholine from presynaptic nerve endings. By engaging in the operation of the cholinergic system, it contributes to improvement of cognitive functions and memory.

Revange Knock Out PM Night GH formula is a product preparing the body to an fficiently night rest. By increasing the concentration of muting neurotransmitters and interfering with the activity of systems: GABA, cholinergic, serotonergic or dopaminergic; it reduces neuronal excitability, reassuring system, through which it supports the process of falling asleep, ensuring high quality sleep.
By reducing a level of stress, anxiety and uncertainty, it gives a sense of well-being, relaxation and allows to create a positive attitude towards the next day. By interfering in cell growth, differentiation, proliferation and development of neurons, improving glucose metabolism in the brain and stimulating the electrophysiological properties of neurons, it improves the development and functioning of the nervous system. By engaging in the work of the cholinergic system, it supports memory processes and a memory formation.
By supporting the endocrine system, mainly through increasing the secretion of growth hormone, it improves the renewal of body structures. It supports the regeneration of muscle and bone tissue and accelerates the decomposition and burning of excessive body fat. Furthermore, by revealing antioxidant and anti-inflammatory properties, it increases the effectiveness of the antioxidant barrier and reduces damages to the circulatory system and many organs. Revenge Knock Out PM is an exceptional preparation, effectively increasing the joy of life after a solid sleep.

Manufacturer

Composition

Composition

Container size: 30 capsulesServing size: 1 capsuleServings per container: 30
per 1 capsuleamount%DV
Phenibut (B-Phenyl-Y-Aminobutyric Acid)250 mg-
GABA (Gamma Aminobutyric Acid)100 mg-
Mucuna Pruriens Extract (98% L-Dopa)100 mg-
5-HTP (5-Hydroxytryptophan)100 mg-
Picamilon100 mg-
Valerian Root Extract (min. 0.8% Valerenic Acids)50 mg-
Hops Flower Extract 4:150 mg-
L-Theanine (5-N-ethyl-glutamine)25 mg-
Sulbutiamine20 mg-
Melatonin (N-acetyl-5-methoxytryptamine)10 mg-
Piperine 95%5 mg-
Galantamine4 mg-

Other ingrednients

Magnesium stearate, silicon dioxide
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GABA

Information


GABA (gamma amino butyric acid) is an amino acid neurotransmitter fulfilling the role of suppressing, of which precursor is the glutamate (neurotransmitter) excitatory neurotransmitter. Reduces psychophysical tension and cortisol levels, enhances the synthesis of growth hormone having anti-catabolic and regenerating properties. Higher need for GABA by the organism occurs with overtraining, mental exhaustion of the body (stress, depression). Supplementation sports and for physically active people recommended after and during intense exercise. GABA is available in the form of mono-preparation supplement and multicomponent formulations to support the regeneration of the night regenerateion and relaxation of the nervous system.
Dosage: 0,5-3g daily approx. 1 hour before bedtime (single dose, customarily in supplementation).

L-DOPA

Information

L-DOPA - an amino acid, commonly called Levodopa, enantiomer of L-dihydroxyphenylalanine, belonging to the group of catecholamines. It is present in the human organism on the pathway of adrenaline biosynthesis. It is produced from tyrosine and is a precursor for subsequent reactions of compounds produced in this chain - dopamine, noradrenaline and adrenaline.

Thanks to the ability to cross blood-brain barrier, it is an incredibly effective supplement as for the promotion of cognitive functions and emotional states. It is conducive to the synthesis of dopamine and therefore it promotes its concentration and effectiveness in the organism. In this way, it positively influences the level of motivation and well-being. Due to the presence of dopamine in the extrapyramidal system, where it is responsible for neuromotor coordination, it is used in the therapy of Parkinson’s disease (the etiology of which consists in disturbing the synthesis of this neurotransmitter).

More globally, supplementation with levodopa may be conducive to the synthesis of subsequent catecholamines on the pathway of their biosynthesis, i.e. noradrenaline and final adrenaline. Therefore, it may demonstrate a stimulating effect.

Supplementation with L-DOPA also positively influences the secretion of testosterone and the human growth hormone. Due to its wide effectiveness in the organism, it may be also effectively used in order to promote sexual functions in men.

Tryptophan

Information

Tryptophan is one of the nine essential amino acids that require high protein food consumption, mono-preparation supplements tryptophan, an amino acid type and EAA-day nutrients and protein, which is essential in the process of protein synthesis. A derivative of 5-HTP in the decarboxylation is a precursor of serotonin ((tissue hormone having an effect on blood pressure and peristalsis), and the subsequent processes of melatonin (the hormone sleep). It is used for synthesis of nicotinic acid (niacin, known as vitamin PP). The due to the appetite suppressant is also used in certain weight loss formulations.
Even a small deficiency is dangerous for the course of many physiological processes, can cause the nervous system deterioration of mood, insomnia, and disturbances in the digestive process. Tryptophan deficiency in the long term leads to depression and neurological disorders.
Mono-preparation supplements of tryptophan are recommended as a means of reducing the stress and reducing the feeling of insomnia. A part of the nutritional supplements type of EAA and all-day aminoacids, it is a valuable component of protein supplements. Available in store www.muscle-zone.pl
Doses recommended in supplementation: 500 - 2000 mg at bedtime, alternatively 500 - 1000 mg before meals.

Picamilon

Information

Picamilon is a chemical substance resulting from the combination of molecules of gamma aminobutyric acid (GABA), which is an inhibiting neurotransmitter, made of glutamate (neurotransmitter excitation) with vitamin PP [niacin (soluble liquid) nicotinamide] GABA reduces psychophysical tension and enhances the synthesis of growth hormone. Vitamin PP belongs to the group of vitamin B. It is used in interaction with vitamins B1, B2 and B6 in the synthesis of hormones during lactation. It provides proper functioning of the brain and nervous system. It is helpful in inflammatory conditions of the skin. Required for synthesis of sex hormones, estrogen, testosterone, cortisone, and insulin. It does not lose its properties during manufacturing and storage. By combining GABA with niacin (first study of the formula was made in the Soviet Union [now Russia] in 1969). The formula affects the enhancing of the nervous system, improves concentration and memory, exceeds the blood-brain barrier, where there is a re-synthesis on the partial components. In the sports supplementation the supplement is used rarely.

Valerian

Information

Valerian (Valeriana officinalis) is an herbal plant (a perennial plant growing wild or cultivated), the mediacal raw material is valerian root (Radix Valerianae) and its rhizome (Rhizoma Valerianae cum radicibus), rich in various active ingredients: flavonoids (hesperidin, 6-methylapigenin ), terpenes (pinene, felandren), monoterpenes diterpenes, sesquiterpenes (valerenal, maaliol) glycoside triterpenoid, monoterpenoid alkaloids, essential oils, organic acids, phenols and alcohols, and mineral salts, sedating (improving the quality of sleep), antispasmodics, antiepileptic and mildly psychotropic, do not cause side effects. In the sports supplementation used in preparations to facilitate sleep and to facilitate night recovery (growth hormone booster) available at www.muscle-zone.pl
Dosage:. Depending on the type of raw material

L-glutamine

Information

L-glutamine - amino acid building endogenous proteins, glutamic acid amide. In the human body it is responsible for the synthesis of proteins, acid-base balance and removing ammonia outside of the organism. With the shortage of energy taken from the muscle tissue, glutamine with alanine participate in the process of gluconeogenesis, and participate in the production of glucose substrate. L-glutamine has a direct impact on the proper functioning of the digestive system and immunity of the organism. Participates in the synthesis of one of the most powerful antioxidant - glutathione. It has anti-catabolic potential. It is found naturally in foods of animal and vegetable origin and high protein supplements. Used as mono-preparation or multi-component amino-acid supplements and supplements enhancing biological recovery after exercises, often in combination with BCAA.
Dosage: 5-20 g per day (portioned during the day, and after training and waking up). The minimum dose used in supplementation is 2-15g per 1 serving.


 

Sulbutiamine

Information

Sulbutiamine – a syntetic derivative of vitamin B1, characterised by much higher absorption. It can penetrate biological membranes and cross the blood-brain barrier. According to studies, it shows neuroprotective properties (improves cognitive functions, mainly creativity, motivation and memory) and has health-promoting effects.

Due to its ability to penetrate the brain, it may increase levels of thiamine (to which it is metabolised). This influences greatly the modulation of neurotransmitters (as reported by studies, it increases the amount of dopamine receptors in the brain and is an important cofactor in acetylcholine synthesis) and neurons. Its nootropic effect is connected with the stimulation of metabolism in the central nervous system.

According to some sources, sulbutiamine may be effective also in individuals with different states of anxiety and depression. It has probably the ability to boost confidence and reduce inhibitions in persons with depressive disorders.

Sulbutiamine may be used successfully by athletes. As stated by scientists, it helps increase the body’s endurance, reduce time needed for recovery and boost energy required for physical activity. It may probably speed up blood flow and increase oxygenation levels.

Melatonin

Information

Melatonin - resulting in the largest quantities in the pineal gland pinealocytes - indoleamine, naturally synthesized using N-acetylserotonin created previously with serotonin. Its characteristics manifested by interacting with melatonin receptors MT1, MT2 and MT3 and nuclear receptors. Affecting the operation of the biological clock, it regulates the processes occurring both in the diurnal, and long-term cycle, e.g. annually. It gives the body a signal to sleep. In preparing for the night's rest, system reduces the temperature of the body, lowers blood pressure, slows digestion and adjusts the rate of biochemical changes. Improves mood and attitude to life after a good night's sleep. It has a significant impact on the discharge of hormones of the hypothalamus, pituitary and gonads, particularly follicle stimulating hormone (FSH) and luteinizing (LH), this is reflected in the normalization of reproductive performance. By reducing the expression of ERa, inhibiting the association of estradiol ER-ERE for DNA, and reducing aromatase activity, shows an anti-estrogen action Optimizing growth hormone and cortisol levels, improves night renewal system, the growth of the desired structures and burning of excessive body fat.

5-Methoxytryptamine

Information

5-Methoxytryptamine - a compound naturally occurring in the human organism. Enriched in one acetyl group, it creates a hormone melatonin and it is structurally similar to serotonin. It is also known as mexamine.

Biological activity of 5-metoxytryptamine should be considered due to its structural similarity to serotonin. It is an agonist of serotonin receptors 5-HT1, 5-HT2, 5-HT4, 5-HT6 and 5-HT7. Because of this, it has stimulating influence on the functioning of the organism and increases the level of cyclic adenosine monophosphate in cells. Thanks to this, it stimulates metabolism and increases the effectiveness of stimulating catecholamines. Because of this activity, it is used in fat burners in order to maximize the pace of weight loss.

Some source also suggest the ability of 5-methoxytryptamine to promote cognitive functions.

Galantamine

Information

Galantamine is an alkaloid of natural origin, obtained from bulbs of snowdrops, easily crossing blood-brain barrier and having the ability to reversibly inhibit acetylcholinesterase.

According to the cholinergic hypothesis, currently considered the most probable, Alzheimer's disease is caused by disorders of the cholinergic system. Decreased amount of acetylcholine is also observed. On the basis of this phenomenon, galantamine is applied to patients with Alzheimer’s-type torpor as a medicine.

The mechanism of activity of galantamine is based on increasing the level of acetylcholine - a neurotransmitter taking part in nerve impulse transmission, both in the central and peripheral nervous system. By blocking the enzyme which breaks it down, i.e. acetylcholinesterase (AChE), the increase of the concentration of acetylcholine in the brain takes place.

As an ingredient of dietary supplements, galantamine finds application as a nootropic substance, optimizing cognitive abilities, sharpening senses, improving memory, attention and motivation. Moreover, it is distinguished by a relaxing effect, thanks to which it works well when applied in the evening, facilitating deep and high-quality sleep.

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