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Folates are believed to be sensitive to environmental factors, so I advise carefulness in its storage. They should be stored in a cool, dark and dry place.
The daily dosage of the preparation contains 800 mcg of folates; the amount is sufficient, so there should be no need to increase the dosage. That can only be recommended by a doctor.
Calcium folinate - a metabolite of tetrahydrofolic acid constituting a perfect form of its supplementation. Tetrahydrofolic acid is a biologically active form of folic acid, especially recommended to people dealing with methylation disorders. Folic acid in the active form is at the same time a promotor of this process, but it requires efficient action for its activation, therefore in case of methylation disorders, folates are the only effective form of supplementation of this compound.
Folic acid is mainly associated with pregnancy. In its active form, it is responsible for the regulation of the development of the neural tube of the fetus, which constitutes a key factor, conditioning its proper development. Providing folates is currently indicated as the most effective form of healthy pregnancy prophylaxis.
Another important aspect of the functionality of tetrahydrofolic acid in the organism is its role in the process of methylation. It positively influences the efficiency of transformations of homocysteine to methionine, thanks to which it demonstrates positive influence on the health of the cardiovascular system. The efficiency of this process is also conducive to maintaining the high concentration of S-adenosyl methionine in the organism. This compound demonstrates special influence on maintaining optimal mental functions and healthy liver.
Folinic acid - 5-formyltetrahydrofolate, a biologically active form of folic acid. Its supplementation is recommended especially to people with methylation dysfunctions, as it is essential for the transformation of folic acid to the active folate. Taking into consideration the increasing tendency to disorders in this respect, folates are more and more often recommended as the basic, preferred forms of supplementation with folic acid.
Supplementation with these folates is especially recommended to women who are planning pregnancy or are pregnant. Folic acid in the biologically active form is responsible for regulating the formation of neural tube in the fetus and is conducive to its proper development.
In adults, folates are conducive to optimal methylation processes. It takes part in transforming homocysteine to methionine, thanks to which it demonstrates positive influence on the health of the cardiovascular system. In this way, it positively influences psyche, as the effectiveness of this process is conducive to the production of S-adenosyl methionine with considerable influence on maintaining proper emotional states.
Some sources also indicate the protective influence of folates on the development of cancers. This information, however, is not fully unambiguous. The present state of knowledge suggests that since the optimal supply of folates really decreases the risk of cancer development, its supplementation in excessively high doses may demonstrate the reverse effect.
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