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Glucosamine is a substance, which is poorly absorbed. Therefore, long-lasting application of this substance is recommended (at least 4 months) in order to obtain its effective concentration in tissues.
The effects related to the application of this amino acid are dependent on the dose. People with serious problems are recommended to apply even 3000-4000 mg of the active substance. However, a single dose should be divided into a few smaller portions to avoid unpleasant side-effects in the digestive system.
It was proven that simultaneous application of chondroitin and MSM maximizes the activity of glucosamine.