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Excessive dose of berberine taken in a single dose may contribute to contractions and diarrhea, therefore larger portions should be planned throughout the day. The generally assumed dose of berberine is 900-2000 mg a day, preferably in 3-4 separate doses. A beneficial dose observed in the research was 500 mg of berberine taken 3 times a day. It is recommended to take the preparation with a meal or immediately after eating.