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- Delivery even day after tomorrow
- Foreign shippment from 5.70 $ Every 83.35 $ reduces shipping costs by 2.78 $
01709231594 (mon.-fri 900-1700)
The presence of the MTHFR gene mutation impairs homocysteine remethylation. Increased homocysteine levels increase oxidative stress and are a marker of many diseases, among other things, cardiovascular and neurodegenerative diseases and depression. The content of methylated folic acid, vitamin B12 and B6 in the formula deactives effectively homocysteine.
Vitamin A (retinol) is present in foods of animal origin (fish of the sea, fish, eels, liver, pork and beef, eggs, butter). In the plant products it is present as provitamin A (b-carotene), a powerful antioxidant. The food products containing pro-vitamin A are fruits in yellow and red, including apricots, tomatoes. Necessary in process of building and assimilation of proteins, affects the normal growth of bones and helps the treatment of eye diseases.Iinhibits the excessive action of the thyroid hormone - thyroxine, which simultaneously prevents the deposition of excess vitamin A. Necessary in the sports diet of in the form of food, such as dietary supplements and nutritional supplements.
Vitamin A deficiency causes growth inhibition, flaking and dryness of the skin, impaired night vision (i.e. Night blindness).
Excess of vitamin A leads to calcification of the bones and some soft tissues, and abnormalities in the functioning of glomerulonephritis
Dosage: Specified in IU and it is 5000 IU per day.
Vitamin C (ascorbic acid) it is a vitamin soluble in body fluids, can be taken from foods (fruits and vegetables), or as drug derived synthetically. The largest of its resources can be found in broccoli, Brussels sprout, kale, black currant fruit and hawthorn, citrus fruits, tomatoes, Savoy cabbage, potatoes. In fact, intake of vitamin C of the food products does not limit the absorbed quantity. Vitamin C (ascorbic acid) is a potent antioxidant, it is an antitoxic, increasing the immune system due to the elimination of risk of bacterial contamination. Vitamin C prevents rupture of blood vessels, affects the blood cholesterol level. It substantially increases the absorption of iron. Inhibits the growth of cancer cells. Lowers stress levels.
Vitamin C deficiency causes abnormal development of connective tissue, cracking capillaries, abnormal calcification of bone tissue, impaired absorption of iron, scorbutus. With the lack of vitamin C, all kinds of injuries do not heal up properly. Vitamin C deficiency can be caused by smoking; each cigarette is destroying up to 100 mg of vitamin C.
Dosage: The demand is 60-80 mg daily. It does not limit the ability to consume higher doses. Some side effects may occur only with longer taking of synthetic vitamin C.
Ascorbic acid – vitamin C. Its biologically active form is the L-isomer, which negatively rotates the polarised light, so that it is a dextroisomer (laevorotatory vitamin C does not exist). It is a strong antioxidant; it reduces the amounts of free radicals, which reduces oxidative stress, a factor leading to cell apoptosis, which is why it is indicated to be a cause for premature ageing.
It supports the immune system functions and increases body system immunity. It is an essential element of the collagen synthesis path, which is why it positively affects the condition of connective tissue. Hence, it promotes also wound healing and increases the durability of capillary vessel. It is involved in transformations of tyrosine and carnitine as well as of some nutrients, so that it affects metabolism. It can also have an impact on the nervous system functions, as it reduces mental fatigue.
Higher supply of vitamin C is especially recommended in the periods of more intensive body system burden, after infections and in order to accelerate regeneration. The indications for increased supply of the vitamin are also hard physical work or intensive trainings.
Vitamin D belongs to fat soluble vitamins, occurs in three forms: calciferol (vitamin D1) ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), it is formed under the action of sunlight for at least 15 minutes per day. In the absence of sunlight it should be administered in the diet in the form of fish oil (Vitamin A + D3) and fish oils. It is responsible for the absorption of calcium and phosphorus. It is the building substance of bone tissue particularly necessary during pregnancy, childhood, and for athletes. It is a component of dietary supplements and nutrients among competetive athletes. Deficiency of vitamin D causes children growth inhibition, and rickets.
For adults - deficiency causes osteomalacia.
Excess of vitamin D causes headaches, alopecia, nausea, drowsiness, blurred vision, pain in the long bones, the deposition of calcium deposits.
Dosage: 400 IU units during the day.
Vitamin E (tocopherol) is a fat soluble. Due to its antioxidant action, it is a protection of other vitamins (e.g. Vitamins A). Protects the body against free radicals, strengthens the walls of blood vessels and its capacity, causing their dilation and dissolution of blood clots. With the reduction of coagulation, it is used as an antiatherogenic medicine, it allows for the proper course of pregnancy. In cooperation with selenium it slows the ageing process of cells, strengthening connective tissue. In the food it is present in whole-grain bread, sprout and grains, vegetable oils (soybean, sunflower), soya beans and sunflower seeds, vegetable fat and hen egg yolks. Also it is used in sports medicine in the form of nutrients and supplements.
Vitamin E deficiency reduces building of red blood cells, results in changes in muscle and disorders of pregnancies.
Dosage: for children, 0.5 mg / 1 kg of weight; for adults 10-30 mg per day.
Vitamin K exists in the triad of vitamins: menaquinone (vitamin. K1), menadione (vitamin. K2) and menadione (vitamin. K3), soluble in fat. It is produced by bacteria in the human colon. Natural sources of vitamin. K are: eggs, kale, cauliflower, cabbage, meat, milk, lettuce, spinach, fish oil and liver. The synthetic form is administered to newborns, to reduce the sterility of the gastrointestinal tract. Used as a antihaemorrhagic, due to its participation in the process of prothrombin. Increases antibacterial and antifungal immunity. Prevents abundant bleeding during menstruation of women.
Vitamin K deficiency causes external bleeding and ecchymosis on skin, decreased prothrombin synthesis in the liver (especially while taking antibiotics and sulfanilamide).
Vitamin K1 (phytomenadione or phylloquinone) is a form of vitamin K containing 4 isoprenoid groups (3 saturated and 1 unsaturated). It is synthesized in natural conditions only in plants. We will find it mainly in green leafy vegetables and some vegetable oils; its amount in the green parts of plants is proportional to the amount of chlorophyll contained there.
The organs characterized by the high concentration of vitamin K are mainly the liver (the content of vitamin K1 exceeds the content of MK-7 10 times) and the heart. It is suggested that vitamin K1 is also stored in bone tissue. It is suspected that ca. 90% of the absorbed phytomenadione is subjected to transformations to MK-4 in case of the insufficient supply of menaquinone with diet.
Apart from a well-discovered role in the production of blood coagulation factors, vitamin K1 also shows a wider activity - it may constitute one of the elements of the prophylaxis of osteoporosis, disorders of the nervous system and cancers.
Therefore, supplementation with vitamin K1 may turn out to be very helpful, especially in the area of the process of blood coagulation and bone metabolism.
Sodium is an important component of the intracellular fluids, and is a regulator of acid-base balance. Along with potassium affects the proper of growth and provides the proper functioning of muscles and nerves. The source of acquisition is table salt (NaCl) and bladderwrack, shellfish, bacon, beef, and of plant beets and carrots. People on salt-free diet should avoid, among others, spicy sauces and smoked meats and sausages.
Sodium deficiency is very rare, at heaving sweating after a long effort (e.g. in the marathon).
Excess sodium increases blood pressure (especially for the elderly), edema and increased thirst. Exceeding the daily dose of 14g a day can cause poisoning.
Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
What is methylcobalamin?
Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.
The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.
Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.
Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
Biotin (vitamin H, co-enzyme R) is in a group of B vitamins, due to the presence of sulphur compounds it is involved in the synthesis of ascorbic acid (vitamin C). Also synthesized in the intestines. It enhances the production of hormones and regulates cholesterol levels. It reduces muscle pain. It prevents hair loss and graying of hair. It soothes the skin inflammations. No toxic effects. Often combined with other B group vitamins and vitamin A. The natural sources of biotin are: whole grain bread, yeast, eggs (yolk), milk, brown rice and cheese.
Daily demand: 100-300 mg per day
Calcium (element chem. symbol Ca, atomic no. 20, the group of alkaline earth metals) is the basic building substance of bones and teeth, in which stored is 99% of the element, in the form of hydroxylapatite. When building bones and teeth, phosphorus is very important in the right proportion. It is a base-forming element and activator of many enzymes (ATPase) necessary to release the energy of ATP. It has a significant effect on blood clotting and regulates blood pressure and neuromuscular conductivity. Thanks to the reduced permeability of cell membranes, it soothes the symptoms of food allergies. Calcium is actively involved in the metabolism of iron interacts with vitamins A, C and D and phosphorus, magnesium. Natural source of calcium are animal products (dairy products, sardines, salmon, sprats eaten with bones) and plant products (nuts, soybeans, sunflower seeds). Absorption takes place in the small intestine (less in the colon), it has an effect on the level of lactose, insoluble fibre, organic acids, alkalinity (low pH). The best absorption have organic compounds (lactates, amino acid chelates etc.). Obstructing the absorption of calcium is caused by: phytic acid and oxalic acid as well as excess fat. Scientific studies have confirmed that the combination of calcium, magnesium, boron and vitamin D in dose 3 mg / 24h effectively prevent osteoporosis. Supplements on the market are both mono-preparation supplements (enriched with vitamin D3) and multi-component supplements, available at www.muscle-zone.pl.
Calcium deficiency disorders manifested in the construction of the bones (osteoporosis) and iron metabolism. The symptoms are: rickets, cramps and muscle tremor, osteoporosis.
Excess resulting from an overdose of calcium supplements containing vitamin D3 for children and adults overdose of calcium (hypercalcemia). Symptoms of hypercalcemia are: lack of appetite, vomiting and constipation.
The dosage administered in various publications are inconsistent: 800 - 1000 mg / 24 h (100 - 500 mg / 24h)
The iron part of the dye in the form of the heme (hemoglobin and myoglobin in meat), a non-haem (in plant), and enzymes responsible for transport and storage of oxygen in the body. It occurs in enzymes responsible for: the metabolism of fatty acids, prostaglandin biosynthesis, catabolism of tryptophan. The absorption of iron in plant is lower than in animal products. In plant foods, it is reduced by contained chemicals: phytates and oxalates, also calcium and high acidity (pH factor). Only 8% of the intake of iron is absorbed by the body and transported to the blood. For tts absorption is needed sufficient amount of: cobalt, manganese, copper and vitamin C. Iron itself is essential for the metabolism of B vitamins. Source of acquisition of iron are animal products (meat, organ meats, egg yolks) and plant products (whole grain bread, beans , cocoa, parsley, nuts, soy). Iron is also present in synthetic form as a component of vitamin-mineral and mineral and mono-preparation supplements, often enriched with vitamin C. Supplements containing iron compounds are recommended for athletes during intense training and those on a meatless diet (vegetarians and vegans).
Iron deficiency causes anaemia. Using a large amount of strong coffee or tea hinders the absorption of iron. Symptoms of iron deficiency are: insomnia, diarrhea, impaired body temperature, loss of papillae on the tongue, reduced exercise capacity, and reduced intellectual and psychological efficiency.
Excess iron reduces the absorption of other elements (e.g. zinc, copper), reduced immunity, causing tissue damage of some organs (kidney, liver, heart), increased risk of cancer.
Dosage: 3-12 mg per day.
Iodine - more than two-thirds of iodine is stored in the thyroid gland and it is a component produced by it hormones - thyroxine and triiodothyronine, which are essential in the metabolism of proteins, carbohydrates and minerals and regulating the processes of growth, causing it usefulness in sports supplementation. It is also the ingredient of weight loss products. Regulates and controls body temperature. Natural source of acquisition of iodine are: bladderwrack, seafood, sea fish and onion and vegetables growing in soil containing this element and most of all iodized salt ..
Deficiency of iodine in the body cause hypothyroidism, and consequently overweight, mental slowing (cretinism inclusive). It is the cause of a goitre. Iodine deficiency can be caused by rhodanates and polyphenols (e.g. contained in cabbage and cauliflower), hemagglutinin found in legumes.
Excess iodine can result in inhibition of thyroid hormone synthesis (this happens in a small percentage of cases).
Dosage: Treatment of iodine should be done under medical supervision. Daily demand for adults is 150 mcg. For pregnant women daily demand increases to 175 mcg.
Potassium and sodium regulate the body's water resources, ensuring normal heart rhythm. Maintaining the proper level of potassium provides the proper oxidation of the brain, lowers blood pressure, increases the permeability of cell membranes (as an antagonist of calcium). It is a base-forming element. It is widely used in sports diet before and after training in the form of supplements, nutrients, vitamin-mineral preparations and minerals, concentrates and ready, isotonic and hypertonic beverages. Natural sources of acquisition of potassium are: vegetable products (bananas, citrus fruits, melons, mint leaves, green vegetables, potatoes) and animal products (sea fish, meat). Potassium is present in the form of organic compounds: citric acids, and fumarates gluconates and inorganic (chlorides, sulfates, oxides and carbonates).
Potassium deficiency (hypokalemia): excessive tiredness, headaches and irritability, problems with sleeping, muscle cramps, constipation. Potassium levels may drop sharply in the event of a reduction in blood sugar levels, prolonged starvation, severe diarrhea. They can occur when too much of strong coffee is consumed, with alcohol abuse and when eating too much sweets.
The excess of potassium (hyperkalemia) is often the cause of depression, hypotension, tingling in the extremities.
Magnesium (element from the group of alkaline earth metals, atomic no. 12, a chemical symbol - Mg), one of the most important health microelements, participates in the synthesis process of the disintegration of high energy compounds and processes of transformation of hydrocarbons and fats. It affects the dilation of blood vessels and lower blood pressure, prevents hypercoagulable state. Shortages affect cardiac arrhythmias, malignant muscle cramps, insomnia and anxiety. It is a component of many dietary supplements and found in foods such as whole grain bread, legumes, buckwheat, rice, fish, meat, as well as chocolate, cocoa and nuts.
Dosage of 100 - 500 mg / day
Magnesium citrate is a salt of magnesium and citric acid. It constitutes one of the best assimilable forms of magnesium, which plays many important functions in the organism. It is responsible, among others, for the proper work of the nervous, immune and muscle systems.
Magnesium has calming effect by decreasing the excitability of nerve cells. Thanks to introducing this element to a diet, we may potentially improve sleep quality and reduce the level of stress.
Positive influence on the circulatory system is another feature of magnesium. It prevents hypertension and storage of cholesterol in the walls of blood vessels (arteries), thanks to which it may prevent diseases related to the circulatory system.
Magnesium also plays a considerable role in the process of muscle contraction, therefore it influences the activity of the whole muscle system. It also takes part in the proper synthesis of protein, the process of cell division and proper course of energy metabolism. It helps to maintain healthy teeth and bones and general electrolyte balance in the organism.
Magnesium malate - a form of magnesium which is well-absorbed in the human organism, from which we may derive additional benefits thanks to the presence of malic acid residue. It is engaged in the transformations aiming at energy extraction in the organism, thanks to which supplementation with malate may positively influence energy metabolism.
Another advantage of magnesium malate distinguishing this form among other numerous forms of this element is its ability to bind and neutralize toxic heavy metals. It may be an antidote for their aggregation in the organism, demonstrating neuroprotective effect.
Taking care of the proper magnesium supply is important due to the health of the cardiovascular system. Its insufficient amounts in diet may cause the increase of pressure and disorders of the rhythm of the heart work. Researchers indicate the correlation between magnesium deficiencies and increased risk of heart attack. Because of the health of the circulatory system, the positive influence of magnesium on lipid profile is also important.
Moreover, magnesium is an important element to maintain optimal sugar metabolism. Benefits from its supplementation will be also noticed by people dealing with diabetes, as it was proven that it may limit the development of diabetic polyneuropathy.
Proper supply of magnesium is important also due to the endurance of bone tissue in the organism. Magnesium belongs to the group of elements that build and strengthen the structure of bones.
When talking about magnesium activity, we must not forget about its positive influence on the functions of the nervous system. It is conducive to proper nervous transmission and neuromotor coordination.
Zinc (chemical element from transition group 12) belongs to the trace elements, it helps maintain acid-base balance of the body, protein, energy, lipid and carbohydrate metabolism. It provides bone metabolism and transport of oxygen. It protects the body against free radicals. Necessary for the proper operation of the senses of taste and smell. Positive impact on the process of insulin metabolism in the pancreas. It supports visual adaptation to the dark, has a significant influence on brain function. It is helpful in the treatment of infertility and mental illness.
Zinc deficiency leads to decreased immunity, and growth retardation. Zinc deficiency can occur in case of excessive consumption of simple sugars. In the case of hormonal therapy of women with irregular menstruation, the therapy should be associated with increased consumption of zinc. It can be found in food like: beans, eggs, carrots, beef and pork meat, milk, nuts, citrus fruits, seafood, rice, cottage cheese, lettuce.
Dosage: Daily 12-15 mg zinc. Exceeding the daily dose of 20 mg cause symptoms of poisoning of the body.
Selenium (element, chemical symbol Se, atomic no. 34, from chalcogenide, it is present in several allotropic forms). It is supplied the body with food in the form of seleno-amino acids (selenomethionine - gathering supplies, and selenocysteine – a component of glutathione peroxidase, deiodinase and seleno-proteins). Regulates the functioning of the thyroid gland. It affects the growth and development, including sexual development (by increasing production and sperm motility). It affects the flexibility of the tissue, removes some of the toxins from the body and destroys cancer cells and reduces the severity of menopause in women. Natural products containing selenium are seafood (sea fish, oysters, bladderwrack) and vegetable products (broccoli, onions, wheat germ, bran, tomatoes) and animal products (poultry, eggs). It is also included in the composition of vitamin-mineral and mineral supplements. Selenium supplementation is recommended as a dietary supplement of active people having diet poor in this element, and as a factor increasing the body's immunity.
Selenium deficiency increases the risk of developing cancer and heart disease. Symptoms of selenium deficiency are: cardiomyopathy, growth stoppage, disorders of detoxification processes which may lead to damage to the kidneys and liver.
An excess of selenium can lead to selenosis (the disease, the symptoms are: loss of hair, nail cracks, lesions).
daily demand of selenium for pregnant women 65 mcg; nursing mothers 75 mcg; men 7 mcg.
L-selenomethionine is a selenoamino acid and organic form of selenium. It is a combination of selenium with methionine (about 40% of selenium and 60% of the amino acid methionine per molecule) in which a sulphur molecule is replaced by selenium.
This form is absorbed very effectively via the digestive tract. It is believed that the bioavailability of selenium from L-selenomethionine is even 1.5-2 times greater than its non-organic forms. It is estimated that its bioavailability may exceed 90%. Furthermore, the half-life of L-selenomethionine is much longer than in non-organic forms – it is 252 days. This means that the absorbed selenium is accumulated for a long time in the body.
Selenium is a component of many key biochemical pathways. It helps protect the body from oxidative stress, prevents atherosclerosis, supports the immune system and brain function and optimises thyroid function. It has been demonstrated that selenium as L-selenomethionine may, among others, reduce the secretion of proinflammatory cytokines in female patients with Hashimoto’s thyroiditis..
As a dietary supplement, L-selenomethione is most often used to support thyroid, cardiac and immune function and stabilise cholesterol levels.
Copper - trace mineral that facilitates the introduction of iron into hemoglobin, allowing the correct functioning of antioxidant processes. It is an important component of enzymes that affect the processes of aerobic metabolism, carbohydrate metabolism and in the formation of collagen. With proper diet, do not use supplements containing copper, as an overdose can cause insomnia, hair loss. It occurs in foods such as legumes, offal, plums, seafood. Copper compounds must be used in a responsible way, because many of them have toxic properties.
Dosing: A sufficient amount of copper provides proper diet.
Manganese, of which a natural source is chocolate, grain products with whole grain, nuts, legumes and dried cranberry, is a component of enzymes and their activator. It stimulates the properties and functionality of connective tissue and provides proper functioning of the brain. It affects the function of the pancreas, ensuring proper insulin metabolism and condition of the bone and joints. Magnesium deficiency contributes to serious disorders in synthesis of hyaluronic acid and chondroitin, reduction in insulin sensitivity of tissues, affects bone resorption. Manganese chelates are used in complexometry in chemical analysis and in medicine for the treatment of severe poisoning (antitoxin) by heavy metals, in sports supplementation, manganese impact on the functioning of the locomotor system is used. It is a component of the so-called regenerators of joints and a vitamin-mineralizing and mineralizing supplements.
Chromium (chemical element from transition group of the chromium, chemically active) is actively involved in the metabolism of fats and carbohydrates. It comes in the easily assimilable organic form and inorganic. Along with insulin, as a component of the glucose tolerance factor (GTF), is used in insulin-dependent diabetes treatment, insulin involved in the metabolism of glucose in t proteins transport. Activator of enzymes involved in the metabolism of fats and cholesterol. Available in animal origin products (liver, veal, chicken, turkey meat, oysters) and plant-origin (bananas, broccoli, cereal, wheat germ, spinach). Supplements containing chromium are recommended for fat loss (also thermogenic), and improving the functioning of the body. The sports supplementation used chromium in the form of mono-preparations or in the form of vitamin-mineral minerals supplements.
Chromium deficiency results in impaired glucose, reducing the insulin sensitivity. It causes a decrease in immunity and endurance of the body. It may be a cause of coronary heart disease. Sometimes it causes neurological disorders.
Dosage: A varied diet prevents from the deficiency of chromium in the body.
Dosage: The recommended dose of 50-150 mg per day.
Molybdenum (the element of the chromium groups, atomic no. 42, a chemical symbol Mo) - a trace element involved in the metabolic conversion of carbohydrates and fats and increases the absorption of iron. It is used to treat anaemia. Well affects the mood.. It is a component of many dietary supplements and in foods such as lettuce, cabbage and other leafy green vegetables, whole grains (corn, sunflower, etc.).
Boron - an element of boron group, symbol B, atomic number (Z) - 5, belongs to a group of micronutrients. The organism, it is responsible for the synthesis of nucleic acids and prevents the release of excess calcium from the bones. Is an activator of enzymes in metabolism. It occurs naturally in citrus fruits (grapefruit, bitter orange), legumes, grapes, malt beer. The supplementation is rarely used, mostly in vitamin and a vitamin-mineralizing supplements.
Dosage: the lack of standards for daily consumption. Excess of boron is toxic for the organism.