Creatine is the the most popular and the the most effective dietary supplement (with proven working by clinical trialas). It is synthesized in the body from amino acids L-arginine, glycine, and L-methionine. It is used mostly in so called the phosphagen system (ATP-PC), in which a creation of a higly energetic compound – ATP is the end result. There are also another advantages of using this dietary supplement, which depend on type of creatine used, like increase of aerobic or/and anaerobic endurance; increase of lean body mass, increase of skeletal muscles volume. Moreover creatine can be used in clinical treatment of the heart diseases and the Alzheimer disease (it lowers homocysteine level), in cases of an impairment of immune system (the synthesis of glutathion) and in the cognition disorders.