Apigenin is an organic chemical compound belonging to flavones, isolated for the first time in 1914 from chamomile herb. It is commonly found in grapefruits, oranges, onions, parsley and in many popular spices, such as oregano, thyme, basil, coriander, and cloves.
Apigenin has a number of pro-health properties – it has been proven to show anti-inflammatory, anti-cancer, anti-diabetic and neuroprotective effects. It also seems to have the ability to stimulate neurogenesis in the adult brain.
Apigenin is used not only for pro-health purposes. It is also a valued element of sports supplementation. Researchers have shown that it acts as an inhibitor of CYP2C9 and CD38. Inhibition of their activity translates into an increase in the level of NAD + in the body, which helps to maintain normal body mass, positively affects the physical condition and slows down the aging process of the body. In addition, apigenin may inhibit the expression of the aromatase enzyme, thus contributing to an increase in testosterone levels.
Supplements most often contain Apigenin isolated from grapefruit; chamomile extracts, standardized for the content of apigenin (usually 1%), are less common. It is also available in the form of a mono-preparation and sometimes it can be found in the composition of preparations for athletes.
Dosage: no standards of unit consumption.
In case of apigenin derived from grapefruit, a dose of 50 mg per day is usually used, and in case of chamomile flower extracts (standardized to 1% of apigenin), the recommended dose is about 500 mg.