Berberine – an isoquinoline alkaloid naturally appearing i.a. in common barberry (Berberis vulgaris). Berberine is a substance which has been known for hundreds years, which is attributed strong anti-inflammatory, antioxidant, anticancer, antibacterial (especially when it comes to Gram-positive bacteria), antiviral, antifungal and anti-protozoan properties. This compound regulates proper functioning of the cardiovascular system.
Numerous clinical studies on the activity of berberine confirm its hypoglycemic properties - it decreases the increased glucose level in blood and normalizes lipid profile - influences decreasing the concentration of LDL, total cholesterol and triacylglycerols and increases the level of HDL in blood, i.a. thanks to supporting liver work. There are some studies confirming positive influence of berberine on alleviating the symptoms of polycystic ovary syndrome (PCOS) and acne. This substance also positively influences cognitive functions.
Berberine may decrease the production of glucose in the liver and influence the improvement of tissue sensitivity to insulin. For this reason, supplements with berberine are reccomended as support in the therapy of insulin-resistance, diabetes, metabolic syndrome, excess weight and obesity. Berberine is also the component of dietary supplements supporting weight loss.
With the simultaneous application of medicines, be careful, as berberine may interact with some pharmacologically active substances.