Betaine (N, N, N-trimethylglycine, the TMG) is methyl glycine derivative participating in the conversion of homocysteine to methionine. It is present in food of plant origin and produced by the body in the liver or kidneys. The medicine uses it in the treatment of gastrointestinal and digestive disorders and hyperhomocysteinemia. In the supplements that increase the level of homocysteine used together with glycocyamine, indirectly influences the endogenous synthesis of creatine. There is no mono-preparation supplement containing betaine. Available in creatine stacks and the detoxicating supplements.