Coluracetam (BCI-540, MKC-231) is a synthetic chemical compound of the racetam family. It was designed as a drug for Alzheimer’s disease in 2005 in Japan. Subsequently, it was in-licensed by BrainCell Inc., which conducted the largest number of studies on antidepressant potential of this compound. Nowadays, the agent is enjoying great popularity in the world of medicine and supplementation – apart from nootropic properties, characteristic of all racetams, it has a beneficial impact on mood and treats anxiety-depressive disorders.
The basic mechanism of action of coluracetam is to stimulate the so-called HACE (high-affinity choline uptake). It is critical to the delivery of choline to neurons where it may be converted into acetylcholine. It is commonly known that it is essential to memory formation, is responsible for the process of learning and enhances focus.
Scientists suggest that coluracetam modulates AMPA receptors. It is also important for mental performance. Furthermore, the stimulation of these receptors leads to a better mood and helps eliminate panic attacks.
In supplementation, coluracetam is used alone or in combination with other nootropic substances.
Dosage: No official guidelines.
The most frequently recommended dosage varies from 20 to 200 mg daily.