Orotate (synonyms: tri-creatine ororate, di-creatine ororate), is formed from the combination of molecules of creatine and three or two molecules of orotic acid in one molecule. Orotic acid (vitamin B13) belongs to the group of water soluble vitamins, is involved in the metabolism of folic acid (vitamin M) and vitamin B12. It occurs in plant origim products. It cure multiple sclerosis. It affects the production of energy through the increase of uridine monophosphate (UMP) and the level of 5-phosphoribosyl-1-pyrophosphate (PRPP), increasing storage of glycogen in the muscles. Creatine (β-methylguanidoacetic acid), it is an endogenous substance, synthesized from the acids present in liver and kidney (L-arginine, L-glycine and L-methionine) and the consumption of meat. Its operation provides a level Adenosine triphosphate (ATP), which is an energy carrier, increases the hydration of cells and muscle glycogen stores. In the sports supplementation, creatine is stored in the muscles, which improves energy management, exercise capacity and quick recovery and muscle growth. It has the ergogenic, anabolic and anti-catabolic potential. A combination of these components with the systematic application increases the functional capacity (strength and endurance), increase lean body mass and accelerates of the recovery of the body after exercising. Because of the anabolism of insulin, increasing creatine transport into muscle cells, it is recommended to combine it with supplements that increase insulin sensitivity (and insulin-mimetics). Orotate, is used by athletes practising strength sports, is available as mono-preparation supplements (powders, capsules) or as a base component of the creatine stacks at www.muscle-zone.pl.
Dosage: The dose used should be given by a doctor or dietician, depending on the type of exercise, length of cycle (cycles of short duration, constant supplementation), and the weight:
- The supplementation cycles of 4 - 12 weeks, 5 - 10 g / 24h (in single or divided doses up to 3 servings / 24h)
- Continuous supplementation from 0.03 g - 0.05 g / kg of body weight