MK-677 significantly increases the concentration of GH, IGF-1 and IGFBP-3 (insulin-binding protein-like growth factor-3) - globulin required for proper operation of IGF-1. It does this by receptor activation, growth hormone secretagogue (GHSR). Thanks to the impact on receptors which natural ghrelin agonists is, acquired the title of ghrelin mimetic.
Ghrelin - otherwise the "hunger hormone" peptide compound synthesized primarily by the stomach cells. By increasing the levels of growth hormone effect on the activation pathway AKT / mTOR, intensification of differentiation of satellite cells, improve the function of mitochondria and inhibition of myostatin compound has great potential for growth of muscle tissue. Additional action intensifying the synthesis of cortisol and prolactin, and an inhibitory effect on the hypothalamic-pituitary-gonadal resulting in lower levels of luteinizing hormone (LH) and testosterone, but eliminates the use of ghrelin as an effective anabolic-catabolic supplement.
Ibutamoren in contrast to ghrelin does not increase the level of cortisol and lower it on the contrary. Had no effect on the amount of prolactin and luteinising hormone (LH). It may slightly decrease testosterone levels in total, but no effect on the rate of free testosterone. Thus Ibutamoren is able to produce positive effects attributed grelinie, without showing the negative properties associated with it.