- Activity independent of MTHFR gene mutation
- Supports the normal function of the nervous system
- Safe, methylated form of folate
- Correct homocysteine metabolism
- Supports the normal course of pregnancy
- Regulation of methylation processes
Jarrow Methyl Folate is a dietary supplement containing the latest 4th generation folate - Quatrefolic®, which is the glucosamine salt of 5-methyltetrahydrofolic acid. Generation IV folate is characterized by high activity and bioavailability by the body. One capsule provides 1000 mcg of folate.
Due to the frequent occurrence of MTHFR gene mutations in the population, attention is increasingly being paid to so-called active folates. These are compounds whose activity and bioavailability do not depend on the mutation of the said gene. Folate has been divided into generations, of which Generation III and the latest Generation IV are the active forms of folate. According to studies, active folates surpass the bioavailability of the popular folic acid. Generation IV, the glucosamine salt, has also been shown to be the fastest absorbed and have better bioavailability than generation III folate.
Methyltetrahydrofolate is the biologically active, methylated form of folate. The primary function of folates is to participate in the body's biochemical reactions as coenzymes. They are a source of one-carbon residues necessary for the normal synthesis of DNA, proteins, myelin sheath and amino acid metabolism. Folate is especially needed in cells that divide intensively, including bone marrow cells and fetal tissues.
Folate helps lower homocysteine levels. Homocysteine is a sulfur amino acid whose elevated blood levels increase the risk of cardiovascular disease, including coronary heart disease or cardiovascular incidents. It also promotes the development of mental disorders. Folate is essential for the process of remethylation of homocysteine to methionine, resulting in lower homocysteine levels. Numerous studies confirm the inverse correlation between folate and homocysteine levels in the blood.
Folate promotes balance in the nervous system. Too high levels of homocysteine promote the development of mental and neurodegenerative diseases. Disorders in folate metabolism can activate neurotoxic and apoptotic processes. The effect of folate deficiency on accelerated neuronal aging processes and insufficient synthesis of some neuromediators has also been suggested. Folate deficiency is also frequently found in certain psychiatric disorders, including endogenous depression, psychosis and insomnia.
Complex sources of folate support normal pregnancy and child development. An adequate supply of folate is an essential element in the prevention of fetal congenital malformations, including serious neural tube defects. The incidence rate of these defects is unfortunately still relatively high. According to expert recommendations, women should supplement folate in the form of folic acid during the preconception period and during pregnancy. Folic acid should not be abandoned during pregnancy, but it is also worth including active folate, which will saturate the body with folate faster and effectively support the action of folic acid.
Folate is essential for normal blood-forming processes. Due to its important role in DNA synthesis, folate, along with vitamin B12, is essential for the proper production of erythroblast cell nuclei. When these compounds are deficient, abnormal megaloblasts are formed, which instead of erythrocytes produce enlarged and shorter-lived megalocytes. Ultimately, megaloblastic anemia develops.
In summary, Jarrow Methyl Folate is a dietary supplement that effectively replenishes folic acid deficiencies. The product is recommended as a supplement to a folate-deficient diet, for people with an increased need for folate, in methylation disorders, with elevated homocysteine levels, and in combination with folic acid during pregnancy and preconception.
