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Take 900-1,500 mg a day, that is 1-2 capsules taken 3 times. Research demonstrates that 1,500 mg of berberine taken in three doses is as efficient as 1,500 mg of metformin or 4 mg of glibenclamide, two drugs used for treating type II diabetes.
Take capsules with or shortly after a meal, as that is when glucose and lipid spikes occur.
Do not take too much berberine at once, as it can result in cramping, diarrhoea, an upset stomach; it should always be taken throughout the day. Because berberine easily reacts with other substances, consult a doctor if you take any medication.
Although berberine demonstrates phenomenal effect both in people who try to lose weight and those with glucose-insulin balance problems, it is advised to use the preparation with caution during the period of building muscle mass by healthy and physically active people. Studies show that provoking constant activity of AMPK may decrease the pace of muscle mass growth. Bearing this in mind, in the periods of building muscle mass, it is rather recommended to limit the application of the supplement only to high-carbohydrate meals.
Berberine – an isoquinoline alkaloid naturally appearing i.a. in common barberry (Berberis vulgaris). Berberine is a substance which has been known for hundreds years, which is attributed strong anti-inflammatory, antioxidant, anticancer, antibacterial (especially when it comes to Gram-positive bacteria), antiviral, antifungal and anti-protozoan properties. This compound regulates proper functioning of the cardiovascular system.
Numerous clinical studies on the activity of berberine confirm its hypoglycemic properties - it decreases the increased glucose level in blood and normalizes lipid profile - influences decreasing the concentration of LDL, total cholesterol and triacylglycerols and increases the level of HDL in blood, i.a. thanks to supporting liver work. There are some studies confirming positive influence of berberine on alleviating the symptoms of polycystic ovary syndrome (PCOS) and acne. This substance also positively influences cognitive functions.
Berberine may decrease the production of glucose in the liver and influence the improvement of tissue sensitivity to insulin. For this reason, supplements with berberine are reccomended as support in the therapy of insulin-resistance, diabetes, metabolic syndrome, excess weight and obesity. Berberine is also the component of dietary supplements supporting weight loss.
With the simultaneous application of medicines, be careful, as berberine may interact with some pharmacologically active substances.