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Galantamine is an alkaloid of natural origin, obtained from bulbs of snowdrops, easily crossing blood-brain barrier and having the ability to reversibly inhibit acetylcholinesterase.
According to the cholinergic hypothesis, currently considered the most probable, Alzheimer's disease is caused by disorders of the cholinergic system. Decreased amount of acetylcholine is also observed. On the basis of this phenomenon, galantamine is applied to patients with Alzheimer’s-type torpor as a medicine.
The mechanism of activity of galantamine is based on increasing the level of acetylcholine - a neurotransmitter taking part in nerve impulse transmission, both in the central and peripheral nervous system. By blocking the enzyme which breaks it down, i.e. acetylcholinesterase (AChE), the increase of the concentration of acetylcholine in the brain takes place.
As an ingredient of dietary supplements, galantamine finds application as a nootropic substance, optimizing cognitive abilities, sharpening senses, improving memory, attention and motivation. Moreover, it is distinguished by a relaxing effect, thanks to which it works well when applied in the evening, facilitating deep and high-quality sleep.
Centrophenoxine (meclofenoxate hydrochloride) is a substance designed as an ester of dimethylethanolamine (DMAE) and synthetic para-chlorophenoxyacetic acid (pCPA) by scientists from the French National Center for Scientific Research. It was intended to be used in the treatment of Alzheimer’s disease. Currently, it is as a dietary supplement in many countries and commonly used as a nootropic agent.
The exact mechanism of action of centrophenoxine still remains a mystery. Scientists agree that the substance easily crosses the blood-brain barrier, consequently increasing acetylcholine levels in synaptic vesicles. Furthermore, it boosts cerebral circulation, thereby increasing the supply of oxygen and nutrients to the brain and speeding up the elimination of toxins. In addition, it is believed to have antioxidant properties.
Centrophenoxine is also used to improve memory and cognitive functions. It has been observed to significantly increase mental performance, promote focus, speed up thought processes and aid learning. It also boosts energy and motivation levels in many individuals.
Dosage: No Recommended Dietary Allowance was set.
The most common daily dosage is from 200 to 500 mg.
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