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To improve the methylation processes and support optimal homocysteine metabolism, it is also recommended to ensure the proper supply of B vitamins, especially vitamins B6, B12, and folates.
Increased homocysteine concentration is usually genetically determined due to MTHFR gene mutation, however, it may also increase under the influence of environmental factors such as e.g. alcohol abuse, smoking, improper diet, some medications, and liver diseases.
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Betaine (N, N, N-trimethylglycine, the TMG) is methyl glycine derivative participating in the conversion of homocysteine to methionine. It is present in food of plant origin and produced by the body in the liver or kidneys. The medicine uses it in the treatment of gastrointestinal and digestive disorders and hyperhomocysteinemia. In the supplements that increase the level of homocysteine used together with glycocyamine, indirectly influences the endogenous synthesis of creatine. There is no mono-preparation supplement containing betaine. Available in creatine stacks and the detoxicating supplements.
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