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When supplementing vitamin B12, it is suggested to monitor regularly blood homocysteine levels. When hyperhomocysteinaemia perists despite of vitamin B12 supplementation, it suggested to test for MTHFR gene polymorphism. In the event of mutation, supplementing with other forms of cobalamin than the methylated one is totally pointless.
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What is hydroxocobalamin?
Hydroxocobalamin is one of four available forms of vitamin B12. Its advantage over cyanocobalamin consists in the ease of conversion to biologically active forms. It is sometimes used as an antidote in cyanide poisonings, because of high affinity to its ions. This form of vitamin B12 may be an interesting alternative for people, who for various reasons cannot use methyl group donors and want a better-quality supplement than the popular cyanocobalamin.
Vitamin B12 is incredibly important for maintaining proper energy metabolism and high condition of the nervous system. Because of the influence on neurotransmitter synthesis, it contributes to the improvement of mood and psychological functions. It also takes part in DNA synthesis and creatine production by the possibility of increasing the concentration of SAMe. It also helps to maintain homocysteine level in lower values, as it supports its remethylation to methionine. It also plays an important role in blood-forming processes and regeneration of myelin sheaths in neurons.
Hydroxocobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
Adenosylcobalamin - a biologically active form of vitamin B12, which similarly to its methylated form does not need to undergo additional biochemical transformations in order to enter metabolic pathways in the human organism.
Apart from the best assimilability, adenosylcobalamin is distinguished from other forms of vitamin B12 by its high affinity for regeneration of nervous tissue. It is indicated that this form of cobalamin is engaged in the production of myelin sheaths with key meaning for proper neurotransmission. Apart from this, vitamin B12 is conducive to maintaining optimal functionality of the nervous system, being conducive to the synthesis of neurotransmitters.
Vitamin B12 is also an incredibly important regulator of methylation process, thanks to which its supplementation positively influences metabolism of the whole organism. It is a coenzyme in the conversion reactions of homocysteine to methionine as well as methylmalonyl-CoA to succinyl-CoA. Because of the first reaction, proper supply of vitamin B12 is also conducive to maintaining high concentrations of S-adenosylmethionine, thanks to which it positively influences mental functions.
Moreover, vitamin B12 is a key regulatory factor, taking part in erythropoiesis, i.e. the process of forming red cells. Its improper supply may be the cause of the development of the so-called vitamin B12 deficiency anemia.
Supplementation with vitamin B12 should be considered especially be people on vegetable diets and those who take drugs from the group of proton-pump inhibitors (PPIs) and metformin.