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Many drugs reduce body’s ability to use folates properly. These include: aspirin, cholesterol-lowering drugs, oral contraceptive pills, gastric acid neutralizers, as well as ametopterin, a known cytostatic drug used in cancer therapy and rheumatoid arthritis. When taking these drugs (and many others) the recommended dose of folates is 800-1,000 mcg per day, preferably in the form of 5-MTHF. When taking folates, it is recommended to take an appropriate amount of vitamin B12 in the form of methylcobalamin.
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Vitamin B9 (folic acid, folacin, vitamin M) is part of a complex of B vitamins soluble in water. It takes part in the production of red blood cells, in cooperation with vitamin B12, preventing anaemia progression, its molecules are involved in catalysis of hematopoietic processes. Together with vitamins B6 and B12 it helps in the treatment of hyperhomocysteinemia. It eliminates disturbances in the gastrointestinal tract. It affects the proper functioning of the immune system. Necessary during pregnancy, because its deficiency causes neural tube defects in the fetus. The natural ingredient of yeast, eggs, liver, green vegetables and it is synthesized in the gastrointestinal tract by intestinal bacteria.
Dosage: The daily requirement is 0.1-0.2 mg.
Quatrefolic is the glucosamine salt of (6S)-5-methyltetrahydrofolate and also an active form of folic acid. It is an innovative nutrient (fourth generation folate) which is well soluble in water and thus absorbed effectively by the body. As an organic compound ranked among B vitamins, it is necessary for normal functioning at the cellular level.
Adding folates to a diet is recommended especially to pregnant and lactating women. These compounds may contribute to healthy foetal development. According to studies, their intake may reduce the incidence of pregnancy complications.
Some sources report that folate supplementation supports cardiovascular function (blood production) and contribute to healthy immune function.
Quatrefolic may affect the metabolism of homocysteine whose levels increase in the body over time. Adding it to a diet may thus prevent the development of dementia and maintain healthy cognitive functions which is vital to adults, especially the elderly.
What is 5-methyltetrahydrofolate (5-MTHF)?
5-methyltetrahydrofolate (5-MTHF) is a methylated, biologically active form of folate. It is especially willingly used by people with folic acid metabolism disorders, especially by polymorphisms of the gene coding the production of methyltetrahydrofolate reductase. Using this form allows to skip narrow gorge created by this polymorphism and enjoy all effects induced by folates. It is also a good substitute for synthetic folic acid (pteroylmonoglutamic acid), which in clinical trials demonstrates the ability to increase the frequency of developing cancers.
Folates, also called vitamin B9 have a wide contribution to the development of the nervous system. They contribute to converting homocysteine to methionine and then to s-Adenosyl methionine, which is the main donor of methyl groups. Thanks to this, the condition of the circulatory system is increased, as the amount of pro-inflammatory homocysteine is decreased and the intensity of the production processes of creatine and neurotransmitter synthesis is higher, which is reflected in the reduction of fatigue and better psychological condition.
5-MTHF in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.