- Concentrated curcumin extract 80%
- Synergy of effects (C3 Complex®)
- Enhanced bioavailability (BioPerine®)
- Natural anti-inflammatory agent
- Inhibits NF-kB activation
- Neutralizes free radicals
- Lethal to many pathogens
- Counteracts digestive disorders
- Used in liver failure conditions
- Cancer prevention
- Support for mental function
Doctor's Best Curcumin C3 Complex is a dietary supplement containing as much as 1,000 mg of standardized and concentrated turmeric extract and 5 mg of black pepper extract per serving. Curcumin is known for its anti-inflammatory, anti-cancer and antioxidant properties, while the piperine content helps increase the bioavailability of the formula.
Curcumin is a yellow pigment present in turmeric and ginger. It belongs to the antioxidant family of polyphenols. This compound has been popular for more than 2,500 years, where ancient texts of Ayurveda (the Indian system of medicine) described its many benefits. In traditional medicine, it has been used to treat a variety of conditions, such as asthma, coughs, allergies, jaundice, diarrhea, biliary disorders, anorexia, diabetic wounds, sprains and post-traumatic swelling. Nevertheless, it's clear that it's only modern science that has allowed millions to benefit from the health benefits of consuming this substance.
Curcumin C3 Complex® is obtained from the dried rhizomes of Curcuma longa and standardized to a minimum of 95% curcuminoids. Standardization of herbal preparations is necessary to evaluate the quality of medicines based on the concentration of active substances. The name C3 Complex® refers to the three main compounds contained in the preparation: curcumin, dimethoxy-curcumin and bis-dimethoxy-curcumin.
Antioxidant action
This is the main health-promoting effect of consuming curcumin, and it manifests itself by neutralizing highly unstable molecules (free radicals) that threaten the integrity of cellular structure.
Studies conducted on cultures of human skin cells, prove the protective effect of curcuminoids against the effects of free radicals, and additionally provide information that the combination of their three main representatives can enhance this effect through synergistic action.
Experiments on rats exposed to neurotoxins and consuming curcumin orally show that the compound may have the effect of protecting the structure of brain molecules and promoting levels of glutathione, the main antioxidant present in the human body.
Anti-inflammatory properties
Curcumin has a strong inhibitory effect on macrophage activation and their recruitment to the site of inflammation. In addition, it can reduce inflammation through various mechanisms, among which the most well-known is the inhibition of the factor TNF-a, which induces the production of cytokines and the formation of the inflammatory process.
Other possibilities for blocking inflammatory processes include: reducing the ability of immune cells to enter sites of inflammation, and reducing the exacerbation of already existing inflammation, by reducing the activity of inflammatory enzymes.
In a pilot study among knee osteoarthritis sufferers that lasted 8 months, it was noted that there was a 41% reduction in total disease symptoms from baseline. There was a decrease in pain, stiffness and improvement in their function. The subjects consumed 200mg of curcuminoids containing 75% curcumin per day.
Cancers
The anti-cancer effect of curcumin is believed to be due to its inhibitory effect on NF-kB proteins, which can affect transcription and genetic coding when active. Typically, TNF-a (a pro-inflammatory factor) positively affects NF-kB protein activity inducing cell growth and survival and inflammation.
Curcumin can inhibit the interactions between these two molecules by reducing the activity of F-kB without lowering TNF-a, and furthermore affect the death and inactivation of proteins that contribute to the formation of cancer cells.
Current studies highlight the possible chemopreventive effect of curcumin. Such action is thought to stop, slow down the process of carcinogenesis or reverse already existing changes. In addition, population-based observations, provide us with information that Indians, for example, who consume large amounts of turmeric (1-2g per day), develop some cancers less often than residents of Western countries.
BioPerine® is a standardized extract of black pepper, which is a source of piperine. It has been proven in studies to affect the bioavailability of nutrients (vitamins, minerals, plant substances) by increasing the secretion of digestive juices and slowing gastric and intestinal emptying. As a result, all ingested food components can potentially be exposed for longer for uptake and absorption.
Piperine is also an inhibitor of the glucuronidation process in the liver, which involves the attachment of a glucuronic acid molecule to an active substance (drug, other active substances) to signal its excretion from the body. This process prevents the accumulation of excessive amounts of active substances from supplements and drugs. Ingestion of piperine can reduce the excretion of certain substances and thereby increase their bioavailability, and this is what happens with curcuminoids.
In conclusion, Doctor's Best Curcumin C3 Complex is a supplement with a wide range of health-promoting effects, which it owes primarily to the presence of potent antioxidants, because, as we know, free radicals are responsible for the formation of many diseases.
It is recommended in the prevention of cancer and among people suffering from chronic inflammation (rheumatoid arthritis, osteoarthritis). Therapeutic doses can be used for a long period of time, as they do not cause side effects.
