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Yohimbine is best to take on an empty stomach and 30-45 min before aerobic training. It should be supplemented in a large interval from rich in carbohydrates meals . Yohimbine uses a naturally produced lipolytic hormones which levels are increased during physical effort. It should be taken around training. It works very well combined with caffeine, thermogenics and nitric oxide boosters. The maximum allowed dose may be 10 to 20 mg per day, depending on the individual characteristics of an organism.