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Both vitamins contained in the preparation act synergistically, especially in relation to the osteoarticular system. Taking that into consideration, the product is particularly recommended to people struggling with all kinds of problems related to the musculoskeletal system, in order to support its regeneration and prevention against further damage. People exposed to osteoporotic bone lesions are in particular postmenopausal women and the elderly, hence the preparation is directed to them.
Vitamin K2 does not accumulate in the liver, so doses of 1000 mcg a day are still safe.
Elderly people who take anticoagulants from the group of vitamin K antagonists (warfarin, acenocoumarol), should consult a physician before supplementation
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Vitamin K exists in the triad of vitamins: menaquinone (vitamin. K1), menadione (vitamin. K2) and menadione (vitamin. K3), soluble in fat. It is produced by bacteria in the human colon. Natural sources of vitamin. K are: eggs, kale, cauliflower, cabbage, meat, milk, lettuce, spinach, fish oil and liver. The synthetic form is administered to newborns, to reduce the sterility of the gastrointestinal tract. Used as a antihaemorrhagic, due to its participation in the process of prothrombin. Increases antibacterial and antifungal immunity. Prevents abundant bleeding during menstruation of women.
Vitamin K deficiency causes external bleeding and ecchymosis on skin, decreased prothrombin synthesis in the liver (especially while taking antibiotics and sulfanilamide).
Vitamin D belongs to fat soluble vitamins, occurs in three forms: calciferol (vitamin D1) ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), it is formed under the action of sunlight for at least 15 minutes per day. In the absence of sunlight it should be administered in the diet in the form of fish oil (Vitamin A + D3) and fish oils. It is responsible for the absorption of calcium and phosphorus. It is the building substance of bone tissue particularly necessary during pregnancy, childhood, and for athletes. It is a component of dietary supplements and nutrients among competetive athletes. Deficiency of vitamin D causes children growth inhibition, and rickets.
For adults - deficiency causes osteomalacia.
Excess of vitamin D causes headaches, alopecia, nausea, drowsiness, blurred vision, pain in the long bones, the deposition of calcium deposits.
Dosage: 400 IU units during the day.
Cholecalciferol, or vitamin D3, is an organic chemical that belongs to the family of D vitamins. It is naturally found in fatty fish, fish oil, egg yolks, milk and dairy products. It is also synthesized in the human body. It is formed from 7-dehydrocholesterol present in the keratinocytes of the spinous and the basal layers of the epidermis, and a pre-requisite for initiating this process is the action of 290-315 nm wavelength UVB radiation on the skin.
Cholecalciferol is a biologically inactive compound. In the body, it undergoes enzymatic hydroxylation – first in the liver, with the participation of 25-hydroxylase, when calcidiol is formed and secondly in the kidneys, where under the influence of 1-α-hydroxylase, calcidiol is converted into the final active form – calcitriol.
The most important role of vitamin D3 in the body is the regulation of calcium-phosphate metabolism, which directly affects normal skeletal mineralization. In addition, it is involved in cell proliferation and differentiation, insulin secretion, as well as in some functions of the nervous, endocrine and immune systems.
Cholecalciferol is the most popular form of vitamin D used in dietary supplements. Studies show that supplementation with vitamin D in this form most effectively and rapidly raises the level of 25 (OH) D3 – a metabolite that is a marker of the level of vitamin D in the body.
Dosage: according to RDI standards for individual age groups.
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