6-paradol is a bioactive chemical compound found in some plants of the ginger family. It is found in particularly large amounts in Aframomum melegueta, commonly known as the Grains of Paradise. In studies on animal models, 6-paradol has been shown to positively affect the lipid profile and sugar metabolism – by lowering serum glucose and reducing cholesterol. It also helps to reduce body mass. Such results were obtained even in animals that were fed with an unhealthy, high-fat diet.
Researchers identified several essential mechanisms of 6-paradol activity. They proved that it increases the use of glucose through a separate, non-insulin dependent pathway. In addition, it inhibits the synthesis of lipids in adipocytes. It also has a thermogenic effect – it is able to stimulate the expression of brown adipose tissue that is responsible for the generation of heat.
In supplementation, 6-paradol is mainly used as a support for the process of reducing body fat. It can be found in many slimming preparations. There are also Aframomum melegueta extracts available on the market, standardized for the content of 6-paradol.