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Supplementation with folates is worth combining with the supplementation of vitamin B12, preferably in a highly assimilable, methylated form - methylcobalamin. Such a combination effectively supports proper functioning of the nervous system, prevents the development of megaloblastic anemia and is conducive to the health of the fetus.
Do not exceed the recommended dose. The amount of 5 mg (5 tablets) and more per day may cause stomachache, diarrhea and rash.
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Metafolin® is a stable and bioactive form of folic acid with high bioavailability, patented by the German pharmaceutical company Merck KGaA. After ingestion, the compound may be directly utilised by the body, irrespective of the presence of disorders (e.g. a MTHFR gene mutation) which hinder conversion of other forms of folic acid into their active forms.
The efficacy of Metafolin® has been confirmed by numerous clinical studies. For instance, it has been demonstrated that this is the only form of folic acid which is capable of crossing the blood-brain barrier. What is more, Metafolin®has passed extensive toxicological safety testing.
In supplementation, Metafolin® is used primarily in women planning pregnancy or who are pregnant and individuals with methylation disorders and elevated homocysteine levels. Scientists also suggest that there is a correlation between folic acid deficiency in the cerebrospinal fluid and the risk of dementia and depression. Because of that, it may be effective in the prevention of neurodegenerative diseases and depression.
Metafolin® can be used not only in dietary supplements but also as an addition to drinks and food.
Dosage: according to individual requirements for folic acid.
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