- Contributes to reducing homocysteine levels
- Convenient to use powder form
- Exhibitshepatoprotective effects
- Has anti-catabolic properties
- May improve creatine synthesis
- Supports the methylation process
Life Extension TMG Powder is a dietary supplement containing pure trimethylglycerin (TMG) also known as betaine anhydrous in powder form. The product supports the maintenance of normal homocysteine levels in the body.
TMG (trimethylglycine) also known as betaine anhydrous, is a compound that is an active metabolite of choline. This substance was first detected in red beets(Beta vulgaris), to which it owes its name.
TMG is found in plants (including broccoli, spinach), animals, and also occurs naturally in the human body and is responsible for lowering homocysteine levels, as well as participating in cell reproduction, improving carnitine production and supporting liver function.
TMG as a source of methyl groups
Betaine is a donor of three methyl groups (-CH3), which are key to the conduct of many biochemical reactions. Thanks to them, compounds such as S-adenosylmethionine (SAM), phosphatidylcholine and carnitine can be formed.
By participating in the process of methylation, which involves transferring one methyl group between molecules and then attaching it to the enzyme responsible for a particular function, betaine is a key element responsible for maintaining health.
It is widely believed that problems with methylation, or more specifically mutation of the MTHFR gene, can affect up to 2 people. This results in, among other things, impaired detoxification functions, abnormal synthesis of neurotransmitters and increased homocysteine levels, all of which can lead to increased inflammation, cardiovascular disease and neurodegenerative disorders.
TMG and homocysteine levels
Homocysteine is a sulfur amino acid formed by the metabolism of methionine and cysteine. Hyperhomocysteinemia interferes with hemostasis and negatively affects endothelial cell structure and vascular elasticity, making it one of the risk factors for atherosclerosis and thromboembolic diseases, and can lead to obstetric complications (neural tube defects, miscarriage, fetal growth retardation).
Betaine anhydrous is considered one of the modulators of homocysteine. TMG transfers a methyl group through the enzyme betaine-homocysteine methyltransferase (BHMT), and then converts to dimethylglycine. TMG donates one methyl group to homocysteine, which contributes to its methylation and results in its conversion to methionine.
Research indicates that taking TMG can reduce the level of this amino acid in the body and helps restore its optimal level, which contributes to reducing the risk of vascular disease.
TMG a precursor to creatine
Betaine participates in the synthesis of creatine, so it can contribute to increasing its intracellular level. Creatine exhibits a number of metabolic functions, including participating in the body's energy production, promoting strength gains and possessing anabolic properties, and enhancing recovery.
Anticatabolic properties of betaine
TMG can increase lean body mass and protect against fat accumulation. This amino acid exhibits anabolic activity, which is related to its important role in the methylation process. TMG, by improving methylation reactions, reduces the action of ubiquitin responsible for the activity of catabolic enzymes and the breakdown of muscle proteins.
Hepatoprotective effect of TMG
TMG is a water-soluble substance and belongs to the group of lipotropic substances, so it can counteract or reduce fat accumulation in the liver. In addition, it seems to protect liver cells from hepatotoxic substances, which include ethanol and carbon tetrachloride.
In conclusion, Life Extension, TMG Powder is a dietary supplement recommended to improve overall health and quality of life, particularly for those at risk of elevated levels of homocysteine in the body. In addition, the product is recommended for those wishing to reduce excess body fat, as well as athletes concerned with high levels of muscle tissue.
