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From 3 units only 3.18 $ /Units. -2%
It should be borne in mind that the preparation, depending on the supplementation time, may bring various effects. Mainly after 2-4 hours from application the feeling of sleepiness may appear and the increase of the tendency to fall asleep. Taking melatonin during the day may cause the feeling of sleepiness and body temperature reduction, while taking it in early evening contributes to accelerating the time needed to fall asleep, sleep latency reduction (the estimated time of waiting for sleep) and REM phase.
In case of the lack of problems with falling asleep, but when there are problems with waking up during the night, is it claimed that melatonin should be taken immediately before going to sleep or immediately after waking up at night, while in the situation of problems with falling asleep, the capsule should be taken an hour or even 2 hours before bedtime.
It has been observed that melatonin supplementation around 8-13 hours before the appearance of the lowest body temperature has a stimulating effect on the pace of biological rhythms, i.a. of sleep-wakefulness, prolactin, body temperature and melatonin. Taking the hormone around 1-4 hours after the lowest body temperature, on the other hand, inhibits the course of the above mentioned phases.
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Melatonin - resulting in the largest quantities in the pineal gland pinealocytes - indoleamine, naturally synthesized using N-acetylserotonin created previously with serotonin. Its characteristics manifested by interacting with melatonin receptors MT1, MT2 and MT3 and nuclear receptors. Affecting the operation of the biological clock, it regulates the processes occurring both in the diurnal, and long-term cycle, e.g. annually. It gives the body a signal to sleep. In preparing for the night's rest, system reduces the temperature of the body, lowers blood pressure, slows digestion and adjusts the rate of biochemical changes. Improves mood and attitude to life after a good night's sleep. It has a significant impact on the discharge of hormones of the hypothalamus, pituitary and gonads, particularly follicle stimulating hormone (FSH) and luteinizing (LH), this is reflected in the normalization of reproductive performance. By reducing the expression of ERa, inhibiting the association of estradiol ER-ERE for DNA, and reducing aromatase activity, shows an anti-estrogen action Optimizing growth hormone and cortisol levels, improves night renewal system, the growth of the desired structures and burning of excessive body fat.
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