- Reduces the occurrence of inflammation in arthritic joints
- Positively influences the ejection of testosterone into the blood
- Participates in the regulation of hormone metabolism
- Improves the production of neurotransmitters
- Visible improvement in cognitive function
- Helpful in the fight against depressive illness
- Participates in the process of gene expression
- Immunomodulatory effect
- Protects joint cartilage
- Donor of methyl groups
Doctor's Best SAM-e is the best absorbed form of S-adenosylmethionine on the market. The specially used formula guarantees a broad and multisystem spectrum of action, including improvement of the functioning of the central nervous system, endocrine system, as well as the osteoarticular system, thus stabilizing the immune response of the body.
S-adenosylmethionine is a compound found in the human body, where it acts as a donor of methyl groups. Its presence allows efficient regulation of metabolic processes, as well as the expression of specific genes, thus contributing to the proper functioning of the body as a whole. SAMe has been proven to help stabilize mood, thus its supplementation may prove effective against depression. However, this is not its only use, as cognitive functions are also improved, and there is also a reduction in inflammatory processes, which brings particular relief to those suffering from degenerative joint disease.
The form of S-adenosylmethionine used has the best bioavailability on the market, and once it enters the bloodstream, it is distributed in free form, so it quickly reaches the tissues where it can begin its action.
Methionine and its metabolism
S-adenosylmethionine is formed as a result of the combination of methionine, which is an essential amino acid (the body cannot synthesize it on its own, it must be supplied from outside) and ATP (a molecule produced during energy metabolism). Metabolic processes of methionine are cyclic and include such compounds as S-adenosylhomocysteine and homocysteine.
High levels of the latter in blood serum show potential atherogenic effects (in other words, accelerate the process of atherosclerotic plaque formation in the artery), which is why supplementation with B vitamins (folic acid, B6, B12) is important, as their presence enables the "completion" of the methionine metabolism cycle and prevents the negative effects caused by homocysteine accumulation as well as SAM deficiency.
Importantly - taking SAM does not contribute to the accumulation of this potentially harmful metabolite that is homocysteine, so its use is safe.
Combat depression
Deficiency of S-adenosylmethionine in the central nervous system has been noted by researchers among people with depressive symptoms. There are two explanations for this fact.
One is most likely a folic acid deficiency, while others explain it as an abnormality in the function of the enzyme that controls the ATP-methionine attachment reaction.
Nevertheless, both explanations lead to the fact that the aforementioned "closure" of the methionine metabolism cycle is impossible.
Comparing the administration of SAM to antidepressants leads to surprising conclusions, as an apparent alleviation of disease symptoms has been observed.
In addition, S-adenosylmethionine is a donor of methyl groups, which is particularly important in the synthesis of neurotransmitters such as acetylcholine, serotonin, norepinephrine, dopamine and melatonin, so its supplementation translates into a significant improvement in mood, memory, cognitive function of the body, as well as modulation of the sleep-wake rhythm.
Masculinity at its highest level
The hormone associated with a sense of masculinity is undoubtedly testosterone, which is produced in the testicles. However, this process cannot take place if there is no luteinizing hormone (LH) secreted by the pituitary gland in the environment. It turns out that methylation reactions controlled by SAM are crucial in the process of androgen production, and a deficiency of this substance contributes to testosterone deficiency, which further results in male hormonal imbalance.
Healthy skeletal system
Two groups of people in particular are prone to mechanical injuries to their joints that lead to the development of osteoarthritis - they are hard-training athletes, as well as the elderly. The pain and mobility impairment felt is caused by local inflammation, often treated with non-steroidal inflammatory drugs, which can adversely affect gastric or renal function. Sometimes this effect is circumvented by administering selective COX-2 inhibitors, but these too are not neutral to health.
With help comes S-adenosylmethionine, which, in a study administered to patients, was as effective as drugs in inhibiting the development of inflammation and thus joint pain and dysfunction. This offers great hope for improving osteoarticular function.
In summary, Doctor's Best SAM-e is a highly specialized supplement that acts in a multidirectional manner in its health-promoting aspect. However, it is especially recommended to everyone who cares about a high-quality preparation that takes care of the proper condition of the osteoarticular, endocrine and especially central nervous system.