- The highest quality 1000 mg of methylsulfonylmethane OptiMSM®!
- Participates in the production of many biologically active substances
- Inhibits the development of inflammation and painful conditions
- Strengthens the structure of joint cartilage
- Excellent antioxidant properties
- Contains biologically available sulfur
- Supports regeneration of the musculoskeletal system
- Improves skin condition
Jarrow MSM 1000mg is a dietary supplement containing methylsulfonylmethane, a compound containing bioavailable sulfur, which, in the form of thiol groups, is used to synthesize substances such as collagen, glutathione, as well as enzymes and antibodies.
Methylsulfonylmethane is a chemical compound belonging to hydrocarbon derivatives, which contains a sulfuric acid (VI) residue in its structure. This compound is not naturally synthesized in the human body, but is widely found in primitive plants, which are part of the diet.
MSM and derivative compounds are quite quickly absorbed in the intestines, from where they reach the liver (derivatives of, for example, DMSO are converted there to MSM), then through the bloodstream to the target tissues, and very often in unchanged form MSM is excreted through the renal route.
Mechanism of action
It is postulated that MSM exhibits several spectra of action. The first is the inhibition of inflammatory processes, which involves the inhibition of nuclear factor (NF-κB) activity, resulting in a decrease in the concentration of pro-inflammatory cytokines - IL-1, IL-6, TNF-α. Inducible nitric oxide synthase (iNOS, found in immune-competent cells and involved in free radical generation, as well as mast cell activation), as well as cyclooxygenase-2 (COX-2), responsible for the production of inflammatory prostaglandins, may also be inhibited.
MSM is also classified as an antioxidant, which in molecular mechanisms coincides with anti-inflammatory effects, but also leads to the abolition of the activation of such proteins as p53 (the so-called "guardian of the genome"), JAK/STAT kinases (through which some hormones act), Nrf-2, which ultimately leads to a reduction in the production of harmful free radicals.
Reduction of the concentration of the aforementioned mediators, the presence of which guarantees increased production of free radicals and induction of inflammation, is reflected in the immunomodulatory effect of methylsulfonylmethane, as it prevents overreactive reactions of the immune system. Supplementation with this compound can help alleviate the symptoms of seasonal allergies, which are the result of abnormalities in the functioning of the immune system.
Effects on organ function
Many diseases involve the immune system in terms of its non-specific response - inflammation. This is also the case with osteoarthritis, in which the activity of cells resorbing components of the bone matrix is induced as a result of the continuous action of destructive mechanical forces. They secrete inflammatory mediators, proteolytic enzymes and free radicals, which in the long term cause the progression of changes. Studies show that MSM supplementation reduces inflammatory reactions, and thus may contribute to halting the progression of osteoarthritis.
Importantly for athletes, methylsulfonylmethane has been shown to significantly improve the function of the musculoskeletal system. Degeneration of joint elements reaches not only elderly people, but also people in their prime who actively participate in sports. Intense exertion also causes micro-injuries in muscles, which manifests itself in their soreness and discomfort. MSM has been shown to reduce these negative effects, thus helping to improve the effectiveness of workouts.
All in all, Jarrow MSM 1000mg is a supplement designed for both active, athletic people and those who want to take care of the condition of their joints. The methylsulfonylmethane contained in it will effectively protect the musculoskeletal system from degenerative processes, and the preparation, contained in a capsule of vegetable origin, has been prepared with vegetarians in mind.
