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  • JARROW Nicotinamide Riboside 100mg 60 tab.
  • JARROW Nicotinamide Riboside 100mg 60 tab.
0 0.00 $
Since 2005  sales@mz-store.co.uk  7767803657
Nicotinamide Riboside Nicotinamide Riboside
  • May inhibit considerably the development of atherosclerosis
  • Involved in the combustion of glucose and fatty acids
  • Promotes strongly cellular energy production
  • Protects against oxidising agents
  • Improves the endurance of trained muscles
  • Safe to use
  • Has anti-inflammatory properties

JARROW Nicotinamide Riboside is a dietary supplement with Niagen® –  nicotinamide riboside chloride, a precursor to mitochondrial coenzymes (NAD+, NADP+), substances which are vital for energy production inside cells.

Nicotinamide riboside chloride is a compound which is important especially for the synthesis of NAD+, an intracellular substance involved in the production of energy from fats and carbohydrates required for normal functioning of, among others, neurons and skeletal muscles.

Important element of intracellular metabolism
Niacin (also called vitamin B3/PP) is a compound found in the form of nicotinic acid, nicotinamide and nicotinamide riboside. It is needed for the synthesis of other important molecules with a key role in intracellular metabolism. Even though it can be synthesised in the body from an amino acid (tryptophan), this pathway will not cover its daily requirements. Because of that, supplementation is important.

Vitamin B3 is absorbed via intestines and distributed in all tissues where it is converted to nicotinamide adenine dinucletodide (NAD+) and its phosphate (NADP+) by special enzymes – Nrk1 and Nrk2. NAD+ and NADP+ are coenzymes (non-protein components of enzymes which are critical to their normal function) for dehydrogenases – responsible for intracellular oxidation of high-energy compounds (glucose, fatty acids and their metabolites).

NAD+ participates in “standard” oxidation reactions – among others, in glycolysis, beta-oxidation and the Krebs cycle, resulting in their reduced form (NADH + H+). Owing to oxidative phosphorylation in the respiratory chain (protein complex transferring electrons and protons which oxidise NADH), this form will help obtain water and as many as 36 molecules of ATP (the main high-energy compound inside cells) in the presence of oxygen. NAD+ is used also for anaerobic glycolysis. However, this process is less energetically efficient because the net yield is 2 molecules of ATP.

NAD+ is a coenzyme involved mainly in the oxidation reaction of glucose which does not generate ATP during the so-called pentose phosphate pathway. The obtained NADPH2 is a very important agent which facilitates the reduction of glutathione (it serves as an antioxidant in erythrocytes and protects them against breakdown) and is used, among others, for the synthesis of steroids and fatty acids.

Impact on carbohydrate balance
Niacin administration may contribute to a decrease in glucose levels in diabetics. This effect is associated with the activation of the receptor HM74A which consequently helps improve insulin sensitivity. It is presumed that it affects the depletion of glycogen reserves in skeletal muscles.

Effect on muscle and adipose tissue
The supplementation with the vitamin results in an increase in blood levels of leptin, a hormone which is responsible, among others, for a feeling of satiety. It boosts also levels of adiponectin which sensitises cells to insulin. However, this is a secondary effect of the insulin resistance induced by vitamin B3 (this effect is independent of the receptor HM74A). It has been also observed that it inhibits also the differentiation of adipocytes and reduces oxidative stress in these cells.

Studies report that the administration of NAD+ helped accelerate metabolism in muscle cells and contributed to increased energy expenditure. There was also an increase in muscle endurance because intracellular NADH concentrations increase with the duration of physical activity. This also inhibits its conversion into NAD+ required for the oxidation of energy substrates.

Other properties of vitamin B3
It is also reported that this compound may be probably effective in the treatment of Alzheimer’s disease or Down syndrome or even prevent ageing. Nonetheless, the research is still ongoing.

By affecting receptors HM74A localised on the macrophages, niacin contributes to the activation of intranuclear PPARγ proteins with anti-inflammatory properties. As a consequence, this induces the expression of ABCA1/ABCG1 receptors in the cell membrane and inhibits the formation of foam cells, which are characteristic of atherosclerosis. In addition, a decrease in the activation of NF-kB, p65 and IκBα proteins accounts for its anti-inflammatory properties. In the immune system, vitamin B3 may have an inhibitory effect on the migration of neutrophils into the inflamed area.

Taking into account its other functions inside the cell, this compound has a vital role in the protection of genetic material from harmful effects of oxidative stress and its degradation. It is also involved in the activation of tumour p53 protein which functions as  "the guardian of the genome” in case of serious DNA damage and thus leads the cells to apoptosis, protecting them against malignant transformation.

To sum up, JARROW Nicotinamide Riboside is a supplement recommended to individuals who want to increase energy levels and also minimise skeletal muscle fatigue. It is suggested also for persons willing to support a healthy immune system and protect cells against harmful free radicals.

 

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Since 2005
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Nicotinamide Riboside Nicotinamide Riboside 60 tab.
JARROW FORMULAS
47.43 $

Nicotinamide Riboside 60 tab.

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Fat loss:
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- Delivery even day after tomorrow

- Foreign shippment from 5.78 $ Every 84.20 $ reduces shipping costs by 2.81 $

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sales@mz-store.co.uk

01709231594 (mon.-fri 900-1700)

47.43 $
Notify me of availability

- Delivery even day after tomorrow

- Foreign shippment from 5.78 $ Every 84.20 $ reduces shipping costs by 2.81 $

You have got questions about the product

sales@mz-store.co.uk

01709231594 (mon.-fri 900-1700)

Description
  • May inhibit considerably the development of atherosclerosis
  • Involved in the combustion of glucose and fatty acids
  • Promotes strongly cellular energy production
  • Protects against oxidising agents
  • Improves the endurance of trained muscles
  • Safe to use
  • Has anti-inflammatory properties

JARROW Nicotinamide Riboside is a dietary supplement with Niagen® –  nicotinamide riboside chloride, a precursor to mitochondrial coenzymes (NAD+, NADP+), substances which are vital for energy production inside cells.

Nicotinamide riboside chloride is a compound which is important especially for the synthesis of NAD+, an intracellular substance involved in the production of energy from fats and carbohydrates required for normal functioning of, among others, neurons and skeletal muscles.

Important element of intracellular metabolism
Niacin (also called vitamin B3/PP) is a compound found in the form of nicotinic acid, nicotinamide and nicotinamide riboside. It is needed for the synthesis of other important molecules with a key role in intracellular metabolism. Even though it can be synthesised in the body from an amino acid (tryptophan), this pathway will not cover its daily requirements. Because of that, supplementation is important.

Vitamin B3 is absorbed via intestines and distributed in all tissues where it is converted to nicotinamide adenine dinucletodide (NAD+) and its phosphate (NADP+) by special enzymes – Nrk1 and Nrk2. NAD+ and NADP+ are coenzymes (non-protein components of enzymes which are critical to their normal function) for dehydrogenases – responsible for intracellular oxidation of high-energy compounds (glucose, fatty acids and their metabolites).

NAD+ participates in “standard” oxidation reactions – among others, in glycolysis, beta-oxidation and the Krebs cycle, resulting in their reduced form (NADH + H+). Owing to oxidative phosphorylation in the respiratory chain (protein complex transferring electrons and protons which oxidise NADH), this form will help obtain water and as many as 36 molecules of ATP (the main high-energy compound inside cells) in the presence of oxygen. NAD+ is used also for anaerobic glycolysis. However, this process is less energetically efficient because the net yield is 2 molecules of ATP.

NAD+ is a coenzyme involved mainly in the oxidation reaction of glucose which does not generate ATP during the so-called pentose phosphate pathway. The obtained NADPH2 is a very important agent which facilitates the reduction of glutathione (it serves as an antioxidant in erythrocytes and protects them against breakdown) and is used, among others, for the synthesis of steroids and fatty acids.

Impact on carbohydrate balance
Niacin administration may contribute to a decrease in glucose levels in diabetics. This effect is associated with the activation of the receptor HM74A which consequently helps improve insulin sensitivity. It is presumed that it affects the depletion of glycogen reserves in skeletal muscles.

Effect on muscle and adipose tissue
The supplementation with the vitamin results in an increase in blood levels of leptin, a hormone which is responsible, among others, for a feeling of satiety. It boosts also levels of adiponectin which sensitises cells to insulin. However, this is a secondary effect of the insulin resistance induced by vitamin B3 (this effect is independent of the receptor HM74A). It has been also observed that it inhibits also the differentiation of adipocytes and reduces oxidative stress in these cells.

Studies report that the administration of NAD+ helped accelerate metabolism in muscle cells and contributed to increased energy expenditure. There was also an increase in muscle endurance because intracellular NADH concentrations increase with the duration of physical activity. This also inhibits its conversion into NAD+ required for the oxidation of energy substrates.

Other properties of vitamin B3
It is also reported that this compound may be probably effective in the treatment of Alzheimer’s disease or Down syndrome or even prevent ageing. Nonetheless, the research is still ongoing.

By affecting receptors HM74A localised on the macrophages, niacin contributes to the activation of intranuclear PPARγ proteins with anti-inflammatory properties. As a consequence, this induces the expression of ABCA1/ABCG1 receptors in the cell membrane and inhibits the formation of foam cells, which are characteristic of atherosclerosis. In addition, a decrease in the activation of NF-kB, p65 and IκBα proteins accounts for its anti-inflammatory properties. In the immune system, vitamin B3 may have an inhibitory effect on the migration of neutrophils into the inflamed area.

Taking into account its other functions inside the cell, this compound has a vital role in the protection of genetic material from harmful effects of oxidative stress and its degradation. It is also involved in the activation of tumour p53 protein which functions as  "the guardian of the genome” in case of serious DNA damage and thus leads the cells to apoptosis, protecting them against malignant transformation.

To sum up, JARROW Nicotinamide Riboside is a supplement recommended to individuals who want to increase energy levels and also minimise skeletal muscle fatigue. It is suggested also for persons willing to support a healthy immune system and protect cells against harmful free radicals.

 

Directions for use
Manufacturer

Composition

Composition

Container size: 60 tabletsServing size: 1 tabletServings per container: 60
per portion (1 tablet)amount%DV
Niagen (Nicotinamide Riboside Chloride)100 mg-

Other ingrednients

Calcium phosphate, cellulose, stearic acid (vegetable source), magnesium stearate (vegetable source), silicon dioxide and a food grade coating.

No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.

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Chloride

Information

Chlorine (chemical element from the group of halogens) - in the natural form of gas it is poisonous and water-soluble (until recently used as a disinfectant in the water supply system, now replaced by fluorination). It is chemically active element. It is used in the form of sodium chloride (NaCl) and potassium (KCl). It participates in the process of digestion and maintains acid-base balance in the body, removes toxic products of metabolism in the liver (antitoxin). Natural source of chlorine for the body is salt and bladderwrack.
Chlorine deficiency can occur due to excessive sweating, vomiting, causing digestive tract problems. It also causes loss of hair and teeth.
Excess chlorine, for example. Drink excessive amounts of chlorinated water, destroys bacterial flora and vitamin E.
Dosage: Daily dose should not exceed 15 grams.


 

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